Browsing Department of Neurology by Author "Aschengrau, Ann"

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A Case-Only Analysis of the Interaction between N-Acetyltransferase 2 Haplotypes and Tobacco Smoke on Breast Cancer Etiology

Lash, Timothy L; Bradbury, Brian D; Wilk, Jemma B; Aschengrau, Ann (BioMed Central, 2005-3-21)

INTRODUCTION. N-acetyltransferase 2 is a polymorphic enzyme in humans. Women who possess homozygous polymorphic alleles have a slower rate of metabolic activation of aryl aromatic amines, one of the constituents of tobacco ...
Departure from multiplicative interaction for catechol-O-methyltransferase genotype and active/passive exposure to tobacco smoke among women with breast cancer

Bradbury, Brian D; Wilk, Jemma B; Aschengrau, Ann; Lash, Timothy L (BioMed Central, 2006-1-17)

BACKGROUND Women with homozygous polymorphic alleles of catechol-O-methyltransferase (COMT-LL) metabolize 2-hydroxylated estradiol, a suspected anticarcinogenic metabolite of estrogen, at a four-fold lower rate than women ...

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