Browsing School of Public Health by Subject "Aryl hydrocarbon receptor"

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Direct Assessment of Cumulative Aryl Hydrocarbon Receptor Agonist Activity in Sera from Experimentally Exposed Mice and Environmentally Exposed Humans

Schlezinger, Jennifer J; Bernard, Pamela L; Haas, Amelia; Grandjean, Philippe; Weihe, Pal; Sherr, David H (National Institute of Environmental Health SciencesBoston University Center for Interdisciplinary Research in Environmental Exposures and Health; National Institutes of Health (P01 ES11624, R01 ES006086, R01 ES011681, R01 ES012199); Superfund (2P42ES007381-15); United States Environmental Protection Agency (RD-83075801-0), 2010-05)

BACKGROUND. Aryl hydrocarbon receptor (AhR) ligands adversely affect many biological processes. However, assessment of the significance of human exposures is hampered by an incomplete understanding of how complex mixtures ...
Generalized Concentration Addition Predicts Joint Effects of Aryl Hydrocarbon Receptor Agonists with Partial Agonists and Competitive Antagonists

Howard, Gregory J.; Schlezinger, Jennifer J.; Hahn, Mark E.; Webster, Thomas F. (National Institute of Environmental Health Sciences, 2010-05)

BACKGROUND. Predicting the expected outcome of a combination exposure is critical to risk assessment. The toxic equivalency factor (TEF) approach used for analyzing joint effects of dioxin-like chemicals is a special case ...

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