Browsing School of Public Health by Subject "Lead exposure"

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Cumulative Community-Level Lead Exposure and Pulse Pressure: The Normative Aging Study

Perlstein, Todd; Weuve, Jennifer; Schwartz, Joel; Sparrow, David; Wright, Robert; Litonjua, Augusto; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2007-12)

BACKGROUND. Pulse pressure increases with age in industrialized societies as a manifestation of arterial stiffening. Lead accumulates in the vasculature and is associated with vascular oxidative stress, which can promote ...
HFE H63D Polymorphism as a Modifier of the Effect of Cumulative Lead Exposure on Pulse Pressure: The Normative Aging Study

Zhang, Aimin; Park, Sung Kyun; Wright, Robert O.; Weisskopf, Marc G.; Mukherjee, Bhramar; Nie, Huiling; Sparrow, David; Hu, Howard (National Institute of Environmental Health Sciences, 2010-09)

BACKGROUND. Cumulative lead exposure is associated with a widened pulse pressure (PP; the difference between systolic and diastolic blood pressure), a marker of arterial stiffness and a predictor of cardiovascular disease. ...

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