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Browsing Mathematics and Statistics by Issue Date

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  • Lunetta, Kathryn L; D'Agostino, Ralph B; Karasik, David; Benjamin, Emelia J; Guo, Chao-Yu; Govindaraju, Raju; Kiel, Douglas P; Kelly-Hayes, Margaret; Massaro, Joseph M; Pencina, Michael J; Seshadri, Sudha; Murabito, Joanne M (BioMed Central, 2007-9-19)
    BACKGROUND: Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span. METHODS: We conducted a genome wide association study (Affymetrix 100K SNP GeneChip) ...
  • Jiang, Xiaoyu; Nariai, Naoki; Steffen, Martin; Kasif, Simon; Kolaczyk, Eric (2008)
    BACKGROUND:In the current climate of high-throughput computational biology, the inference of a protein's function from related measurements, such as protein-protein interaction relations, has become a ...
  • Roopun, Anita K.; Kramer, Mark A.; Carracedo, Lucy M.; Kaiser, Marcus; Davies, Ceri H.; Traub, Roger D.; Kopell, Nancy J.; Whittington, Miles A. (Frontiers Research Foundation, 2008-04-08)
    The neocortex generates rhythmic electrical activity over a frequency range covering many decades. Specific cognitive and motor states are associated with oscillations in discrete frequency bands within this range, but it ...
  • Roopun, Anita K.; Kramer, Mark A.; Carracedo, Lucy M.; Kaiser, Marcus; Davies, Ceri H.; Traub, Roger D.; Kopell, Nancy J.; Whittington, Miles A. (Frontiers Research Foundation, 2008-12-15)
    Multiple local neuronal circuits support different, discrete frequencies of network rhythm in neocortex. Relationships between different frequencies correspond to mechanisms designed to minimise interference, couple activity ...
  • Lin, Hong Huang; Ray, Surajit; Tongchusak, Songsak; Reinherz, Ellis L; Brusic, Vladimir (BioMed Central, 2008-3-16)
    BACKGROUND: Protein antigens and their specific epitopes are formulation targets for epitope-based vaccines. A number of prediction servers are available for identification of peptides that bind major histocompatibility ...
  • Holloway, Dustin T; Kon, Mark; DeLisi, Charles (BioMed Central, 2008-5-30)
    BACKGROUND. An important goal in post-genomic research is discovering the network of interactions between transcription factors (TFs) and the genes they regulate. We have previously reported the development of a ...
  • Holloway, Dustin T; Kon, Mark; DeLisi, Charles (BioMed Central, 2008-6-18)
    BACKGROUND. An important goal in bioinformatics is to unravel the network of transcription factors (TFs) and their targets. This is important in the human genome, where many TFs are involved in disease progression. Here, ...
  • Jiang, Xiaoyu; Nariai, Naoki; Steffen, Martin; Kasif, Simon; Kolaczyk, Eric D (BioMed Central, 2008-8-22)
    BACKGROUND. In the current climate of high-throughput computational biology, the inference of a protein's function from related measurements, such as protein-protein interaction relations, has become a canonical task. Most ...
  • Kramer, Mark A.; Roopun, Anita K.; Carracedo, Lucy M.; Traub, Roger D.; Whittington, Miles A.; Kopell, Nancy J. (Public Library of Science, 2008-9-5)
    Rhythmic voltage oscillations resulting from the summed activity of neuronal populations occur in many nervous systems. Contemporary observations suggest that coexistent oscillations interact and, in time, may switch in ...
  • Cheng, Susan; Massaro, Joseph M.; Fox, Caroline S.; Larson, Martin G.; Keyes, Michelle J.; McCabe, Elizabeth L.; Robins, Sander J.; O'Donnell, Christopher J.; Hoffmann, Udo; Jacques, Paul F.; Booth, Sarah L.; Vasan, Ramachandran S.; Wolf, Myles; Wang, Thomas J. (American Diabetes Association, 2009-10-15)
    OBJECTIVE: Because vitamin D deficiency is associated with a variety of chronic diseases, understanding the characteristics that promote vitamin D deficiency in otherwise healthy adults could have important clinical ...
  • Lee, Shane; Sen, Kamal; Kopell, Nancy (Public Library of Science, 2009-12-11)
    Spike timing dependent plasticity (STDP) has been observed experimentally in vitro and is a widely studied neural algorithm for synaptic modification. While the functional role of STDP has been investigated extensively, ...
  • Jain, Shilpa H.; Massaro, Joseph M.; Hoffmann, Udo; Rosito, Guido A.; Vasan, Ramachandran S.; Raji, Annaswamy; O'Donnell, Christopher J.; Meigs, James B.; Fox, Caroline S. (American Diabetes Association, 2009-2-17)
    OBJECTIVE: To test the association of regional fat depots with circulating adiponectin and resistin concentrations and to assess the potential mediating effect of adipokines on associations between abdominal fat depots and ...
  • Sam, Susan; Haffner, Steven; Davidson, Michael H.; D'Agostino, Ralph B.; Feinstein, Steven; Kondos, George; Perez, Alfonso; Mazzone, Theodore (American Diabetes Association, 2009-2-19)
    OBJECTIVE: Both visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) have been linked to systemic inflammation in nondiabetic cohorts. We examined the relationships between VAT and SAT and systemic inflammatory ...
  • Porter, Stacy A.; Massaro, Joseph M.; Hoffmann, Udo; Vasan, Ramachandran S.; O'Donnel, Christopher J.; Fox, Caroline S. (American Diabetes Association, 2009-3-5)
    OBJECTIVE: Obesity is associated with increased metabolic and cardiovascular risk. The ectopic fat hypothesis suggests that subcutaneous fat may be protective, but this theory has yet to be fully explored. RESEARCH DESIGN ...
  • Sam, Susan; Haffner, Steven; Davidson, Michael H.; D'Agostino, Ralph B.; Feinstein, Steven; Kondos, George; Perez, Alfonso; Mazzone, Theodore (American Diabetes Association, 2009-7-10)
    OBJECTIVE: Greater accumulation of visceral fat is strongly linked to risk of cardiovascular disease. However, elevated waist circumference by itself does not always identify individuals with increased visceral fat. RESEARCH ...
  • Ducrocq, Gregory; Wallace, Joshua S.; Baron, Gabriel; Ravaud, Philippe; Alberts, Mark J.; Wilson, Peter W.F.; Ohman, Erik Magnus; Brennan, Danielle M.; D'Agostino, Ralph B.; Bhatt, Deepak L.; Steg, Philippe Gabriel (Oxford University Press, 2010-02-24)
    AIMS. To develop a risk score to quantify bleeding risk in outpatients with or at risk of atherothrombosis. METHODS AND RESULTS. We studied patients in the REACH Registry, a cohort of 68 236 patients with/at risk of ...
  • Kopell, Nancy; Kramer, Mark A.; Malerba, Paola; Whittington, Miles A. (Frontiers Research Foundation, 2010-11-02)
    This essay discusses the relationship between the physiology of rhythms and potential functional roles. We focus on how the biophysics underlying different rhythms can give rise to different abilities of a network to form ...
  • Wolongevicz, Dolores M.; Zhu, Lei; Pencina, Michael J.; Kimokoti, Ruth W.; Newby, P. K.; D'Agostino, Ralph B.; Millen, Barbara E. (Hindawi Publishing Corporation, 2010-1-5)
    Background. Links between dietary quality and abdominal obesity are poorly understood. Objective. To examine the association between an obesity-specific dietary quality index and abdominal obesity risk in women. Methods. ...
  • Chen, Ming-Huei; Larson, Martin G; Hsu, Yi-Hsiang; Peloso, Gina M; Guo, Chao-Yu; Fox, Caroline S; Atwood, Larry D; Yang, Qiong (BioMed Central, 2010-5-14)
    BACKGROUND. Genome-wide association (GWA) studies that use population-based association approaches may identify spurious associations in the presence of population admixture. In this paper, we propose a novel three-stage ...
  • Cosgrove, Elissa J; Gardner, Timothy S; Kolaczyk, Eric D (BioMed Central, 2010-9-9)
    BACKGROUND. Transcriptional regulatory network inference (TRNI) from large compendia of DNA microarrays has become a fundamental approach for discovering transcription factor (TF)-gene interactions at the genome-wide level. ...

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