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Browsing Chemistry by Title

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  • Voevodski, Konstantin; Teng, Shang-Hua; Xia, Yu (BioMed Central, 2009-9-18)
    BACKGROUND. Protein-protein interactions (PPIs) play fundamental roles in nearly all biological processes, and provide major insights into the inner workings of cells. A vast amount of PPI data for various organisms is ...
  • Mulcahy, Seann P. (2012-01-03)
    A microwave-accelerated synthesis of volatile aromatic esters is described in this convenient Fisher esterification reaction. Students perform a liquid-liquid extraction to isolate crude product which they purify by ...
  • Mulcahy, Seann P. (2011-10-15)
    An introductory laboratory on the identification of analgesics in an unknown sample. Ideal for the first week of an organic chemistry sequence to get students familiar with their surroundings. Students extract, isolate, ...
  • Linghu, Bolan; Snitkin, Evan S; Hu, Zhenjun; Xia, Yu; DeLisi, Charles (BioMed Central, 2009-09-03)
    An evidence-weighted functional-linkage network of human genes reveals associations among diseases that share no known disease genes and have dissimilar phenotypes. We integrate 16 genomic features to construct an ...
  • Mulcahy, Seann P. (2011-10-11)
    A convenient preparation of substituted benzoic acids from Grignard additions to solid carbon dioxide. Students create a library of carboxylic acids by using differentially substituted, commercially available aryl bromides, ...
  • Xia, Yu; Franzosa, Eric A.; Gerstein, Mark B. (Public Library of Science, 2009-6-12)
    Rates of evolution differ widely among proteins, but the causes and consequences of such differences remain under debate. With the advent of high-throughput functional genomics, it is now possible to rigorously assess the ...
  • Mulcahy, Seann P. (2011-07-14)
    A two-week multi-step experiment that introduces students to mechanistic organic chemistry and substituent effects. A simple preparation of differentially substituted para-nitrophenyl benzoates is followed by ester hydrolysis ...
  • Mulcahy, Seann P.; Evans, Thomas; Rossi, Lauren (2011-07-14)
    Excellent laboratory procedure for a small focused library of dihydropyrimidinones. Good example of a multicomponent reaction performed using microwave irradiation.
  • Snyder, John K. (2012-10-26)
    Examples of NMR problems used in various homeworks and exams for sophomore organic chemistry
  • Snyder, John K. (2012-10-26)
    Additional NMR problems for sophomore organic chemistry
  • Wang, Yong; Zhang, Xiang-Sun; Xia, Yu (2009-10)
    Transcriptional cooperativity among several transcription factors (TFs) is believed to be the main mechanism of complexity and precision in transcriptional regulatory programs. Here, we present a Bayesian network framework ...
  • Wang, Yong; Franzosa, Eric A.; Zhang, Xiang-Sun; Xia, Yu (Oxford University Press, 2010-5-13)
    When averaged over the full yeast protein–protein interaction and transcriptional regulatory networks, protein hubs with many interaction partners or regulators tend to evolve significantly more slowly due to increased ...
  • Mulcahy, Seann P. (2011-07-14)
    A simple, solventless procedure for reductive amination that results in an impressive color change. Reaction proceeds in three stages: imine formation, reduction, and acetylation and purification is done by crystallization.
  • Kim, Philip M; Sboner, Andrea; Xia, Yu; Gerstein, Mark (Nature Publishing Group, 2008-03-25)
    Recent studies have emphasized the value of including structural information into the topological analysis of protein networks. Here, we utilized structural information to investigate the role of intrinsic disorder in these ...
  • Gao, Yang; Wolf, Lauren K.; Georgiadis, Rosina M. (Oxford University Press, 2006-07-05)
    The hybridization kinetics for a series of designed 25mer probe–target pairs having varying degrees of secondary structure have been measured by UV absorbance and surface plasmon resonance (SPR) spectroscopy in solution ...
  • Gao, Yang; Wolf, Lauren K.; Georgiadis, Rosina M. (2006)
    The hybridization kinetics for a series of designed 25mer probe�target pairs having varying degrees of secondary structure have been measured by UV absorbance and surface plasmon resonance (SPR) spectroscopy ...
  • Voevodski, Konstantin; Teng, Shang-Hua; Xia, Yu (BioMed Central, 2009-11-29)
    BACKGROUND. Protein-protein interaction (PPI) networks enable us to better understand the functional organization of the proteome. We can learn a lot about a particular protein by querying its neighborhood in a PPI network ...
  • Snyder, John K. (2012-10-19)
  • Plasterer, Thomas N; Smith, Temple F; Mohr, Scott C (BioMed Central, 2001-06-01)
    BACKGROUND. We have constructed Bayesian prior-based, amino-acid sequence profiles for the complete yeast mitochondrial proteome and used them to develop methods for identifying and characterizing the context of protein ...
  • Mulcahy, Seann P. (2012-01-03)
    An easy preparation of differentially-substituted biaryls is reported by palladium-catalyzed cross coupling. The Suzuki cross coupling reaction is both fast and substituent-independent. Column chromatography is performed ...

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