CAS: Chemistry: Scholarly Papers
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URI: http://hdl.handle.net/2144/1001
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Intercepted retro-Nazarov reaction: syntheses of amidino-rocaglate derivatives and their biological evaluation as eIF4A inhibitors
(2019-08-14)Rocaglates are a family of natural products isolated from the genus Aglaia which possess a highly substituted cyclopenta[b]benzofuran skeleton and inhibit cap-dependent protein synthesis. Rocaglates are attractive compounds ... -
Tracing MYC expression for small molecule discovery
(Cell Press, 2019-05-16)Our inability to effectively "drug" targets such as MYC for therapeutic purposes requires the development of new approaches. We report on the implementation of a phenotype-based assay for monitoring MYC expression in ... -
Regiodivergent photocyclization of dearomatized acylphloroglucinols: asymmetric syntheses of (—)-nemorosone and (—)-6-epi-garcimultiflorone A
(ACS Publications, 2019-07-17)Regiodivergent photocyclization of dearomatized acylphloroglucinol substrates has been developed to produce type A polycyclic polyprenylated acylphloroglucinol (PPAP) derivatives using an excited-state intramolecular proton ... -
Translation inhibition by rocaglates activates a species-specific cell death program in the emerging fungal pathogen Candida auris
(American Society for Microbiology, 2020-03-10)Fungal infections are a major contributor to infectious disease-related deaths worldwide. Recently, global emergence of the fungal pathogen Candida auris has caused considerable concern because most C. auris isolates are ... -
Rocaglates induce gain-of-function alterations to eIF4A and eIF4F
(Elsevier Inc., 2020-02-25)Rocaglates are a diverse family of biologically active molecules that have gained tremendous interest in recent years due to their promising activities in pre-clinical cancer studies. As a result, this family of compounds has ... -
Meta-analysis and systematic review of skin graft donor-site dressings with future guidelines.
(2018-09)Background: Many types of split-thickness skin graft (STSG) donor-site dressings are available with little consensus from the literature on the optimal dressing type. The purpose of this systematic review was to analyze ... -
Hybrid plasmonic photoreactors as visible light-mediated bactericides
(2020-01-08)Photocatalytic compounds and complexes, such as tris(bipyridine)ruthenium(II), [Ru(bpy)3]2+, have recently attracted attention as light-mediated bactericides that can help to address the need for new antibacterial strategies. ... -
Sustainable polycarbonate adhesives for dry and aqueous conditions with thermoresponsive properties
(2019-12-02)Pressure sensitive adhesives are ubiquitous in commodity products such as tapes, bandages, labels, packaging, and insulation. With single use plastics comprising almost half of yearly plastic production, it is essential ... -
LSF small molecule inhibitors phenocopy LSF-targeted siRNAs causing mitotic defects and senescence in cancer cells
The oncogene LSF has been proposed as a novel target with therapeutic potential for multiple cancers. LSF overexpression correlates with poor prognosis for both liver and colorectal cancers, for which there are currently ... -
Improvement of experimental testing and network training conditions with genome-wide microarrays for more accurate predictions of drug gene targets
(BioMed Central, 2014)BACKGROUND: Genome-wide microarrays have been useful for predicting chemical-genetic interactions at the gene level. However, interpreting genome-wide microarray results can be overwhelming due to the vast output of gene ...
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