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  Chemical tunnel-splitting-engineering in a dysprosium-based molecular nanomagnet 

  Sorensen, Mikkel A.; Hansen, Ursula B.; Perfetti, Mauro; Pedersen, Kasper S.; Bartolome, Elena; Simeoni, Giovanna G.; Mutka, Hannu; Rols, Stephane; Jeong, Minki; Zivkovic, Ivica; Retuerto, Maria; Arauzo, Ana; Bartolome, Juan; Piligkos, Stergios; Weihe, Hogni; Doerrer, Linda H.; van Slageren, Joris; Ronnow, Henrik M.; Lefmann, Kim; Bendix, Jesper (Nature Publishing Group, 2018-03-29)

  Total control over the electronic spin relaxation in molecular nanomagnets is the ultimate goal in the design of new molecules with evermore realizable applications in spin-based devices. For single-ion lanthanide systems, ...
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  Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs 

  Nalli, Ancy D.; Brown, Lauren E.; Thomas, Cheryl L.; Sayers, Thomas J.; Porco, John A.; Henrich, Curtis J. (Nature Publishing Group, 2018-11-30)

  Rocaglamide has been reported to sensitize several cell types to TRAIL-induced apoptosis. In recent years, advances in synthetic techniques have led to generation of novel rocaglamide analogs. However, these have not been ...
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  A photochemical flow reactor for large scale syntheses of aglain and rocaglate natural product analogues 

  Yueh, Han; Gao, Qiwen; Porco, John A.; Beeler, Aaron B. (PERGAMON-ELSEVIER SCIENCE LTD, 2017-12-01)

  Herein, we report the development of continuous flow photoreactors for large scale ESIPT-mediated [3+2]-photocycloaddition of 2-(p-methoxyphenyl)-3-hydroxyflavone and cinnamate-derived dipolarophiles. These reactors can ...
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  High-throughput screening in larval zebrafish identifies novel potent sedative-hypnotics 

  Yang, Xiaoxuan; Jounaidi, Youssef; Dai, Jennifer B.; Marte-Oquendo, Francisco; Halpin, Elizabeth S.; Brown, Lauren E.; Trilles, Richard; Xu, Wenqing; Daigle, Renee; Yu, Buwei; Schaus, Scott E.; Porco, John A.; Forman, Stuart A. (LIPPINCOTT WILLIAMS & WILKINS, 2018-09-01)

  BACKGROUND: Many general anesthetics were discovered empirically, but primary screens to find new sedative-hypnotics in drug libraries have not used animals, limiting the types of drugs discovered. The authors hypothesized ...
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  Experimental maps of DNA structure at nucleotide resolution distinguish intrinsic from protein-induced DNA deformations 

  Azad, Robert N.; Zafiropoulos, Dana; Ober, Douglas; Jiang, Yining; Chiu, Tsu-Pei; Sagendorf, Jared M.; Rohs, Remo; Tullius, Thomas D. (Oxford University Press, 2018-03-16)

  Recognition of DNA by proteins depends on DNA sequence and structure. Often unanswered is whether the structure of naked DNA persists in a protein–DNA complex, or whether protein binding changes DNA shape. While X-ray ...
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  Deuterated nucleotides as chemical probes of RNA structure: a detailed protocol for the enzymatic synthesis of a complete set of nucleotides specifically deuterated at ribose carbons 

  Tullius, Tom; Ingle, Shakti; Azad, Robert

  We describe here a detailed protocol for the synthesis of ribonucleotides specifically deuterated at each ribose carbon atom. We synthesized 20 specifically deuterated ribonucleotides: ATP, CTP, GTP, and UTP, each of which ...
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  GBshape: a genome browser database for DNA shape annotations 

  Chiu, Tsu-Pei; Yang, Lin; Zhou, Tianyin; Main, Bradley J.; Parker, Stephen C.J.; Nuzhdin, Sergey V.; Tullius, Thomas D.; Rohs, Remo (Oxford University Press, 2014-10-17)

  Many regulatory mechanisms require a high degree of specificity in protein-DNA binding. Nucleotide sequence does not provide an answer to the question of why a protein binds only to a small subset of the many putative ...
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  Chemical probing of RNA with the hydroxyl radical at single-atom resolution 

  Ingle, Shakti; Azad, Robert N.; Jain, Swapan S.; Tullius, Thomas D. (Oxford University Press, 2014-11-10)

  While hydroxyl radical cleavage is widely used to map RNA tertiary structure, lack of mechanistic understanding of strand break formation limits the degree of structural insight that can be obtained from this experiment. ...
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  Rocaglates as dual-targeting agents for experimental cerebral malaria 

  Langlais, David; Cencic, Regina; Moradin, Neda; Kennedy, James M.; Ayi, Kodjo; Brown, Lauren E.; Crandall, Ian; Tarry, Michael J.; Schmeing, Martin; Kain, Kevin C.; Porco, John A.; Pelletier, Jerry; Gros, Philippe (National Academy of Sciences, 2018-03-06)

  Cerebral malaria (CM) is a severe and rapidly progressing complication of infection by Plasmodium parasites that is associated with high rates of mortality and morbidity. Treatment options are currently few, and intervention ...
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  Secondary structure effects on DNA hybridization kinetics: a solution versus surface comparison 

  Gao, Yang; Wolf, Lauren K.; Georgiadis, Rosina M. (2006)

  The hybridization kinetics for a series of designed 25mer probe-target pairs having varying degrees of secondary structure have been measured by UV absorbance and surface plasmon resonance (SPR) spectroscopy in solution ...

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