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  Secondary structure effects on DNA hybridization kinetics: a solution versus surface comparison 

  Gao, Yang; Wolf, Lauren K.; Georgiadis, Rosina M. (2006)

  The hybridization kinetics for a series of designed 25mer probe-target pairs having varying degrees of secondary structure have been measured by UV absorbance and surface plasmon resonance (SPR) spectroscopy in solution ...
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  Worldwide malaria incidence and cancer mortality are inversely associated 

  Liu, P.

  BACKGROUND: Investigations on the effects of malaria infection on cancer mortality are limited except for the incidence of Burkitt’s lymphoma (BL) in African children. Our previous murine lung cancer model study demonstrated ...
• Benzobisoxazole cruciforms: a tunable, cross-conjugated platform for the generation of deep blue OLED materials 

  Chavez, Ramiro; Cai, Min; Tlach, Brian; Wheeler, David L.; Kaudal, Rajiv; Tsyrenova, Ayuna; Tomlinson, Aimee L.; Shinar, Ruth; Shinar, Joseph; Jeffries-EL, Malika (Royal Society of Chemistry, 2016-01-01)

  Four new cross-conjugated small molecules based on a central benzo[1,2-d:4,5-d′]bisoxazole moiety possessing semi-independently tunable HOMO and LUMO levels were synthesized and the properties of these materials were ...
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  Total synthesis of aurofusarin: studies on the atropisomeric stability of bis-naphthoquinones 

  Qi, Chao; Wang, Wenyu; Reichl, Kyle D.; McNeely, James; Porco, John A. (2018-02-19)

  An efficient annulation involving pyrone addition to a quinone and Dieckmann condensation was developed for rapid assembly of a γ-naphthopyrone monomeric precursor to the bis-naphthoquinone natural product aurofusarin. ...
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  Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma 

  Manier, Salomon; Huynh, Daisy; Shen, Yu J.; Zhou, Jia; Yusufzai, Timur; Salem, Karma Z.; Ebright, Richard Y.; Shi, Jiantao; Park, Jihye; Glavey, Siobhan V.; Devine, William G.; Liu, Chia-Jen; Leleu, Xavier; Quesnel, Bruno; Roche-Lestienne, Catherine; Snyder, John K.; Brown, Lauren E.; Gray, Nathanael; Bradner, James; Whitesell, Luke; Porco, John A.; Ghobrial, Irene M. (American Association for the Advancement of Science (AAAS), 2017)

  Multiple myeloma (MM) is a frequently incurable hematological cancer in which overactivity of MYC plays a central role, notably through up-regulation of ribosome biogenesis and translation. To better understand the oncogenic ...
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  Synthesis of isochromene-type scaffolds via single-flask Diels-Alder-[4 + 2]-annulation sequence of a silyl-substituted diene with menadione 

  Lee, Jihoon; Panek, James S. (2014-06-20)

  A sequential Diels-Alder reaction/silicon-directed [4 + 2]-annulation was developed to assemble hydroisochromene-type ring systems from menadione 2. In the first step, a Diels-Alder of the 1-silyl-substituted butadiene 1 ...
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  Disulfide-mediated stabilization of the IκB kinase binding domain of NF-κB essential modulator (NEMO) 

  Zhou, Li; Yeo, Alan T.; Ballarano, Carmine; Weber, Urs; Allen, Karen N.; Gilmore, Thomas D.; Whitty, Adrian (2014-12-23)

  Human NEMO (NF-κB essential modulator) is a 419 residue scaffolding protein that, together with catalytic subunits IKKα and IKKβ, forms the IκB kinase (IKK) complex, a key regulator of NF-κB pathway signaling. NEMO is an ...
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  Structure of a rabbit muscle fructose-1,6-bisphosphate aldolase A dimer variant 

  Sherawat, Manashi; Tolan, Dean R.; Allen, Karen N. (2008-05)

  Fructose-1,6-bisphosphate aldolase (aldolase) is an essential enzyme in glycolysis and gluconeogenesis. In addition to this primary function, aldolase is also known to bind to a variety of other proteins, a property that ...
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  nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs 

  Gandin, Valentina; Masvidal, Laia; Hulea, Laura; Gravel, Simon-Pierre; Cargnello, Marie; McLaughlan, Shannon; Cai, Yutian; Balanathan, Preetika; Morita, Masahiro; Rajakumar, Arjuna; Furic, Luc; Pollak, Michael; Porco, John A.; St-Pierre, Julie; Pelletier, Jerry; Larsson, Ola; Topisirovic, Ivan (2016-03-14)

  The diversity of MTOR-regulated mRNA translation remains unresolved. Whereas ribosome-profiling suggested that MTOR almost exclusively stimulates translation of the TOP (terminal oligopyrimidine motif) and TOP-like mRNAs, ...
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  Syntheses of (+)-30-epi-, (-)-6-epi-, (±)-6,30-epi-13,14-didehydroxyisogarcinol and (±)-6,30-epi-garcimultiflorone A utilizing highly diastereoselective, Lewis acid-controlled cyclizations 

  Boyce, Jonathan H.; Eschenbrenner-Lux, Vincent; Porco, John A. (2016-11-09)

  The first syntheses of 13,14-didehydroxyisogarcinol (6) and garcimultiflorone A (5) stereoisomers are reported in six steps from a commercially available phloroglucinol. Lewis acid-controlled, diastereoselective cationic ...

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