CAS: Chemistry: Scholarly Papers
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URI: http://hdl.handle.net/2144/1001
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High-throughput screening in larval zebrafish identifies novel potent sedative-hypnotics
(LIPPINCOTT WILLIAMS & WILKINS, 2018-09-01)BACKGROUND: Many general anesthetics were discovered empirically, but primary screens to find new sedative-hypnotics in drug libraries have not used animals, limiting the types of drugs discovered. The authors hypothesized ... -
GBshape: a genome browser database for DNA shape annotations
(Oxford University Press, 2014-10-17)Many regulatory mechanisms require a high degree of specificity in protein-DNA binding. Nucleotide sequence does not provide an answer to the question of why a protein binds only to a small subset of the many putative ... -
Deuterated nucleotides as chemical probes of RNA structure: a detailed protocol for the enzymatic synthesis of a complete set of nucleotides specifically deuterated at ribose carbons
We describe here a detailed protocol for the synthesis of ribonucleotides specifically deuterated at each ribose carbon atom. We synthesized 20 specifically deuterated ribonucleotides: ATP, CTP, GTP, and UTP, each of which ... -
Experimental maps of DNA structure at nucleotide resolution distinguish intrinsic from protein-induced DNA deformations
(Oxford University Press, 2018-03-16)Recognition of DNA by proteins depends on DNA sequence and structure. Often unanswered is whether the structure of naked DNA persists in a protein–DNA complex, or whether protein binding changes DNA shape. While X-ray ... -
Chemical probing of RNA with the hydroxyl radical at single-atom resolution
(Oxford University Press, 2014-11-10)While hydroxyl radical cleavage is widely used to map RNA tertiary structure, lack of mechanistic understanding of strand break formation limits the degree of structural insight that can be obtained from this experiment. ... -
Rocaglates as dual-targeting agents for experimental cerebral malaria
(National Academy of Sciences, 2018-03-06)Cerebral malaria (CM) is a severe and rapidly progressing complication of infection by Plasmodium parasites that is associated with high rates of mortality and morbidity. Treatment options are currently few, and intervention ... -
Secondary structure effects on DNA hybridization kinetics: a solution versus surface comparison
(2006)The hybridization kinetics for a series of designed 25mer probe-target pairs having varying degrees of secondary structure have been measured by UV absorbance and surface plasmon resonance (SPR) spectroscopy in solution ... -
Worldwide malaria incidence and cancer mortality are inversely associated
BACKGROUND: Investigations on the effects of malaria infection on cancer mortality are limited except for the incidence of Burkitt’s lymphoma (BL) in African children. Our previous murine lung cancer model study demonstrated ... -
Benzobisoxazole cruciforms: a tunable, cross-conjugated platform for the generation of deep blue OLED materials
(Royal Society of Chemistry, 2016-01-01)Four new cross-conjugated small molecules based on a central benzo[1,2-d:4,5-d′]bisoxazole moiety possessing semi-independently tunable HOMO and LUMO levels were synthesized and the properties of these materials were ... -
Total synthesis of aurofusarin: studies on the atropisomeric stability of bis-naphthoquinones
(2018-02-19)An efficient annulation involving pyrone addition to a quinone and Dieckmann condensation was developed for rapid assembly of a γ-naphthopyrone monomeric precursor to the bis-naphthoquinone natural product aurofusarin. ...
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