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  Synthesis of isochromene-type scaffolds via single-flask Diels-Alder-[4 + 2]-annulation sequence of a silyl-substituted diene with menadione 

  Lee, Jihoon; Panek, James S. (2014-06-20)

  A sequential Diels-Alder reaction/silicon-directed [4 + 2]-annulation was developed to assemble hydroisochromene-type ring systems from menadione 2. In the first step, a Diels-Alder of the 1-silyl-substituted butadiene 1 ...
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  Disulfide-mediated stabilization of the IκB kinase binding domain of NF-κB essential modulator (NEMO) 

  Zhou, Li; Yeo, Alan T.; Ballarano, Carmine; Weber, Urs; Allen, Karen N.; Gilmore, Thomas D.; Whitty, Adrian (2014-12-23)

  Human NEMO (NF-κB essential modulator) is a 419 residue scaffolding protein that, together with catalytic subunits IKKα and IKKβ, forms the IκB kinase (IKK) complex, a key regulator of NF-κB pathway signaling. NEMO is an ...
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  Structure of a rabbit muscle fructose-1,6-bisphosphate aldolase A dimer variant 

  Sherawat, Manashi; Tolan, Dean R.; Allen, Karen N. (2008-05)

  Fructose-1,6-bisphosphate aldolase (aldolase) is an essential enzyme in glycolysis and gluconeogenesis. In addition to this primary function, aldolase is also known to bind to a variety of other proteins, a property that ...
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  nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs 

  Gandin, Valentina; Masvidal, Laia; Hulea, Laura; Gravel, Simon-Pierre; Cargnello, Marie; McLaughlan, Shannon; Cai, Yutian; Balanathan, Preetika; Morita, Masahiro; Rajakumar, Arjuna; Furic, Luc; Pollak, Michael; Porco, John A.; St-Pierre, Julie; Pelletier, Jerry; Larsson, Ola; Topisirovic, Ivan (2016-03-14)

  The diversity of MTOR-regulated mRNA translation remains unresolved. Whereas ribosome-profiling suggested that MTOR almost exclusively stimulates translation of the TOP (terminal oligopyrimidine motif) and TOP-like mRNAs, ...
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  A novel class of small molecule compounds that inhibit hepatitis C virus infection by targeting the prohibitin-CRaf pathway 

  Liu, Shufeng; Wang, Wenyu; Brown, Lauren E.; Qiu, Chao; Lajkiewicz, Neil; Zhao, Ting; Zhou, Jianhua; Porco, John A.; Wang, Tony T. (2015-11)

  Identification of novel drug targets and affordable therapeutic agents remains a high priority in the fight against chronic hepatitis C virus (HCV) infection. Here, we report that the cellular proteins prohibitin 1 (PHB1) ...
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  Divergent total syntheses of rhodomyrtosones A and B 

  Gervais, Anais; Lazarski, Kiel E.; Porco, John A. (2015-10-02)

  Herein, we report total syntheses of the tetramethyldihydroxanthene natural product rhodomyrtosone B and the related bis-furan β-triketone natural product rhodomyrtosone A. Nickel-(II)-catalyzed 1,4-conjugate addition of ...
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  Syntheses of dimeric tetrahydroxanthones with varied linkages: investigation of "shapeshifting" properties 

  Qin, Tian; Iwata, Takayuki; Ransom, Tanya T.; Beutler, John A.; Porco, John A. (2015-12-09)

  The 2,4'- and 4,4'-linked variants of the cytotoxic agent secalonic acid A and their analogues have been synthesized. Kinetic resolution of an unprotected tetrahydroxanthone scaffold followed by copper-mediated biaryl ...
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  Translation inhibition by rocaglates is independent of eIF4E phosphorylation status 

  Chu, Jennifer; Cencic, Regina; Wang, Wenyu; Porco, John A.; Pelletier, Jerry (2016-01)

  Rocaglates are natural products that inhibit protein synthesis in eukaryotes and exhibit antineoplastic activity. In vitro biochemical assays, affinity chromatography experiments coupled with mass spectrometry analysis, ...
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  Syntheses of (+)-30-epi-, (-)-6-epi-, (±)-6,30-epi-13,14-didehydroxyisogarcinol and (±)-6,30-epi-garcimultiflorone A utilizing highly diastereoselective, Lewis acid-controlled cyclizations 

  Boyce, Jonathan H.; Eschenbrenner-Lux, Vincent; Porco, John A. (2016-11-09)

  The first syntheses of 13,14-didehydroxyisogarcinol (6) and garcimultiflorone A (5) stereoisomers are reported in six steps from a commercially available phloroglucinol. Lewis acid-controlled, diastereoselective cationic ...
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  Asymmetric syntheses of the flavonoid Diels-Alder natural products sanggenons C and O 

  Qi, Chao; Xiong, Yuan; Eschenbrenner-Lux, Vincent; Cong, Huan; Porco, John A. (2016-01-27)

  Metal-catalyzed, double Claisen rearrangement of a bis-allyloxyflavone has been utilized to enable a concise synthesis of the hydrobenzofuro[3,2-b]chromenone core structure of the natural products sanggenon A and sanggenol ...

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