CAS: Chemistry: Scholarly Papers
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URI: http://hdl.handle.net/2144/1001
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Surface enhanced Raman spectroscopy of Chlamydia trachomatis and Neisseria gonorrhoeae for diagnostics, and extra-cellular metabolomics and biochemical monitoring
(NATURE PUBLISHING GROUP, 2018-03-26)SERS spectra excited at 785 nm of the bacteria Chlamydia trahomatis (elementary bodies, EB) and Neisseria gonorrheoae, the causative pathogens for the two most common sexually transmitted diseases (STD), chlamydia and ... -
Incorporating an online interactive video platform to optimize active learning and improve student accountability through educational videos
(American Chemical Society (ACS), 2020-12-08)Video learning holds an important place in modern STEM classrooms, but more improvements to the learning experience are needed. In order to introduce active-learning components into assignments, questions are often deployed ... -
Step back, translate, extend: addressing misconceptions relating to energy and free energy in cellular reactions via active-learning videos
(2020-11)In order to succeed in biochemistry, students must transfer and build upon their understanding of general chemistry and introductory biology concepts. One such critical area of knowledge is bioenergetics. Student misconceptions ... -
Teaching fundamental skills in Microsoft Excel to first-year students in quantitative analysis
(AMER CHEMICAL SOC, 2015-11-01)Despite their technological savvy, most students entering university lack the necessary computer skills to succeed in a quantitative analysis course, in which they are often expected to input, analyze, and plot results of ... -
Effective and inexpensive HPLC analogue for first-year students: buret chromatography of food dyes in drinks
(American Chemical Society, 2019-03-04)Chromatography is a ubiquitous technique in analytical chemistry, and high-performance liquid chromatography (HPLC) is the industry standard for quantitation of components in solution mixtures. However, demonstrating the ... -
An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris
(2020-12-22)Candida auris is an emerging fungal pathogen that exhibits resistance to multiple drugs, including the most commonly prescribed antifungal, fluconazole. Here, we use a combinatorial screening approach to identify a ... -
Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer
(2020-12-07)In the colon, long-term exposure to chronic inflammation drives colitis-associated colon cancer (CAC) in patients with inflammatory bowel disease. While the causal and clinical links are well established, molecular ... -
Biomimetic synthesis of meroterpenoids by dearomatization-driven polycyclization
(2019-11-04)A biomimetic route to farnesyl pyrophosphate and dimethyl orsellinic acid (DMOA)-derived meroterpenoid scaffolds has yet to be reported despite great interest from the chemistry and biomedical research communities. A concise ... -
Amidino-rocaglates: a potent class of eIF4A inhibitors
(2019-11-21)Rocaglates share a common cyclopenta[b]benzofuran core that inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase, eIF4A. Working as interfacial inhibitors, rocaglates stabilize the ... -
Gold(I)-mediated cycloisomerization/cycloaddition enables bioinspired syntheses of neonectrolides B-E and analogues
(2019-09-25)Development of a synthetic route to the oxaphenalenone (OP) natural products neonectrolides B-E is described. The synthesis relies on gold-catalyzed 6-endo-dig hydroarylation of an unusual enynol substrate as well as a ...
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