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  • Instability of pulses in gradient reaction-diffusion systems: a symplectic approach 

    Beck, Margaret A.; Latushkin, Yuri; Cox, Graham; Mcquighan, Kelly; Jones, Christopher; Sukhtayev, Alim
    In a scalar reaction-diffusion equation, it is known that the stability of a steady state can be determined from the Maslov index, a topological invariant that counts the state's critical points. In particular, this implies ...
  • Slopes of modular forms and the ghost conjecture 

    Pollack, Robert J.; Bergdall, John (2017-05)
    We formulate a conjecture on slopes of overconvergent p-adic cusp forms of any p-adic weight in the Gamma_0(N)-regular case. This conjecture unifies a conjecture of Buzzard on classical slopes and more recent conjectures ...
  • Probabilistic Protein Function Prediction from Heterogeneous Genome-Wide Data 

    Nariai, Naoki; Kolaczyk, Eric D.; Kasif, Simon (Public Library of Science, 2007-3-28)
    Dramatic improvements in high throughput sequencing technologies have led to a staggering growth in the number of predicted genes. However, a large fraction of these newly discovered genes do not have a functional assignment. ...
  • A Three-Stage Approach for Genome-Wide Association Studies with Family Data for Quantitative Traits 

    Chen, Ming-Huei; Larson, Martin G.; Hsu, Yi-Hsiang; Peloso, Gina M.; Guo, Chao-Yu; Fox, Caroline S.; Atwood, Larry D.; Yang, Qiong (BioMed Central, 2010-5-14)
    BACKGROUND. Genome-wide association (GWA) studies that use population-based association approaches may identify spurious associations in the presence of population admixture. In this paper, we propose a novel three-stage ...
  • Identification of Polymorphisms Explaining a Linkage Signal: Application to the GAW14 Simulated Data 

    Chen, Ming-Huei; Van Eerdewegh, Paul; Dupuis, Josée (BioMed Central, 2005-12-30)
    We applied three approaches for the identification of polymorphisms explaining the linkage evidence to the Genetic Analysis Workshop 14 simulated data: 1) the genotype-IBD sharing test (GIST); 2) an approach suggested by ...
  • Integration of Relational and Hierarchical Network Information for Protein Function Prediction 

    Jiang, Xiaoyu; Nariai, Naoki; Steffen, Martin; Kasif, Simon; Kolaczyk, Eric D. (BioMed Central, 2008-8-22)
    BACKGROUND. In the current climate of high-throughput computational biology, the inference of a protein's function from related measurements, such as protein-protein interaction relations, has become a canonical task. Most ...
  • Joint Modeling of Linkage and Association Using Affected Sib-Pair Data 

    Chen, Ming-Huei; Cui, Jing; Guo, Chao-Yu; Cupples, L Adrienne; Van Eerdewegh, Paul; Dupuis, Josée; Yang, Qiong (BioMed Central, 2007-12-18)
    There has been a growing interest in developing strategies for identifying single-nucleotide polymorphisms (SNPs) that explain a linkage signal by joint modeling of linkage and association. We compare several existing ...
  • Classifying Transcription Factor Targets and Discovering Relevant Biological Features 

    Holloway, Dustin T.; Kon, Mark; DeLisi, Charles (BioMed Central, 2008-5-30)
    BACKGROUND. An important goal in post-genomic research is discovering the network of interactions between transcription factors (TFs) and the genes they regulate. We have previously reported the development of a ...
  • Rhythm Generation through Period Concatenation in Rat Somatosensory Cortex 

    Kramer, Mark A.; Roopun, Anita K.; Carracedo, Lucy M.; Traub, Roger D.; Whittington, Miles A.; Kopell, Nancy J. (Public Library of Science, 2008-9-5)
    Rhythmic voltage oscillations resulting from the summed activity of neuronal populations occur in many nervous systems. Contemporary observations suggest that coexistent oscillations interact and, in time, may switch in ...
  • Machine Learning for Regulatory Analysis and Transcription Factor Target Prediction in Yeast 

    Holloway, Dustin T.; Kon, Mark; DeLisi, Charles (Kluwer Academic Publishers, 2006-10-31)
    High throughput technologies, including array-based chromatin immunoprecipitation, have rapidly increased our knowledge of transcriptional maps-the identity and location of regulatory binding sites within genomes. Still, ...

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