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  • PleioGRiP: Pleiotropic Genetic Risk Prediction via Bayesian model search and classification 

    Sebastiani, Paola; Hartley, Stephen (2012-11-16)
    The program PleioGRiP performs a genome-wide Bayesian model search to identify SNPs associated with a discrete phenotype, and uses SNPs ranked by Bayes factor to produce nested Bayesian classifiers. These classifiers can ...
  • Routine HIV Screening in France: Clinical Impact and Cost-Effectiveness 

    Yazdanpanah, Yazdan; Sloan, Caroline E.; Charlois-Ou, Cécile; Le Vu, Stéphane; Semaille, Caroline; Costagliola, Dominique; Pillonel, Josiane; Poullié, Anne-Isabelle; Scemama, Olivier; Deuffic-Burban, Sylvie; Losina, Elena; Walensky, Rochelle P.; Freedberg, Kenneth A.; Paltiel, A. David (Public Library of Science, 2010-10-1)
    BACKGROUND. In France, roughly 40,000 HIV-infected persons are unaware of their HIV infection. Although previous studies have evaluated the cost-effectiveness of routine HIV screening in the United States, differences in ...
  • Population-Based Rates of Revision of Primary Total Hip Arthroplasty: A Systematic Review 

    Corbett, Kelly L.; Losina, Elena; Nti, Akosua A.; Prokopetz, Julian J. Z.; Katz, Jeffrey N. (Public Library of Science, 2010-10-20)
    BACKGROUND. Most research on failure leading to revision total hip arthroplasty (THA) is reported from single centers. We searched PubMed between January 2000 and August 2010 to identify population- or community-based ...
  • Transmissibility of the Influenza Virus in the 1918 Pandemic 

    White, Laura Forsberg; Pagano, Marcello (Public Library of Science, 2008-1-30)
    BACKGROUND. With a heightened increase in concern for an influenza pandemic we sought to better understand the 1918 Influenza pandemic, the most devastating epidemic of the previous century. METHODOLOGY/PRINCIPAL FINDINGS. ...
  • Assessing the Performance of a Computer-Based Policy Model of HIV and AIDS 

    Rydzak, Chara E.; Cotich, Kara L.; Sax, Paul E.; Hsu, Heather E.; Wang, Bingxia; Losina, Elena; Freedberg, Kenneth A.; Weinstein, Milton C.; Goldie, Sue J. (Public Library of Science, 2010-9-9)
    BACKGROUND. Model-based analyses, conducted within a decision analytic framework, provide a systematic way to combine information about the natural history of disease and effectiveness of clinical management strategies ...
  • Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and Non-Hispanic Whites 

    Mattei, Josiemer; Parnell, Laurence D.; Lai, Chao-Qiang; Garcia-Bailo, Bibiana; Adiconis, Xian; Shen, Jian; Arnett, Donna; Demissie, Serkalem; Tucker, Katherine L.; Ordovas, Jose M. (BioMed Central, 2009-8-14)
    BACKGROUND. Variations in gene allele frequencies can contribute to differences in the prevalence of some common complex diseases among populations. Natural selection modulates the balance in allele frequencies across ...
  • A Three-Stage Approach for Genome-Wide Association Studies with Family Data for Quantitative Traits 

    Chen, Ming-Huei; Larson, Martin G.; Hsu, Yi-Hsiang; Peloso, Gina M.; Guo, Chao-Yu; Fox, Caroline S.; Atwood, Larry D.; Yang, Qiong (BioMed Central, 2010-5-14)
    BACKGROUND. Genome-wide association (GWA) studies that use population-based association approaches may identify spurious associations in the presence of population admixture. In this paper, we propose a novel three-stage ...
  • Consistency of Linkage Results across Exams and Methods in the Framingham Heart Study 

    Atwood, Larry D.; Heard-Costa, Nancy L.; Cupples, L. Adrienne; Levy, Daniel (BioMed Central, 2003-12-31)
    BACKGROUND. The repeated measures in the Framingham Heart Study in the Genetic Analysis Workshop 13 data set allow us to test for consistency of linkage results within a study across time. We compared regression-based ...
  • Genetics Analysis Workshop 16 Problem 2: tTe Framingham Heart Study Data 

    Cupples, L. Adrienne; Heard-Costa, Nancy; Lee, Monica; Atwood, Larry D. (BioMed Central, 2009-12-15)
    Genetic Analysis Workshop 16 (GAW16) Problem 2 presented data from the Framingham Heart Study (FHS), an observational, prospective study of risk factors for cardiovascular disease begun in 1948. Data have been collected ...
  • Automated MRI Measures Identify Individuals with Mild Cognitive Impairment and Alzheimer's Disease* 

    Desikan, Rahul S.; Cabral, Howard J.; Hess, Christopher P.; Dillon, William P.; Glastonbury, Christine M.; Weiner, Michael W.; Schmansky, Nicholas J.; Greve, Douglas N.; Salat, David H.; Buckner, Randy L.; Fischl, Bruce (Oxford University Press, 2009-5-21)
    Mild cognitive impairment can represent a transitional state between normal ageing and Alzheimer's disease. Non-invasive diagnostic methods are needed to identify mild cognitive impairment individuals for early therapeutic ...

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