URI: http://hdl.handle.net/2144/1019

Recently Added

  • Automated MRI Measures Identify Individuals with Mild Cognitive Impairment and Alzheimer's Disease* 

    Desikan, Rahul S.; Cabral, Howard J.; Hess, Christopher P.; Dillon, William P.; Glastonbury, Christine M.; Weiner, Michael W.; Schmansky, Nicholas J.; Greve, Douglas N.; Salat, David H.; Buckner, Randy L.; Fischl, Bruce (Oxford University Press, 2009-5-21)
    Mild cognitive impairment can represent a transitional state between normal ageing and Alzheimer's disease. Non-invasive diagnostic methods are needed to identify mild cognitive impairment individuals for early therapeutic ...
  • Prognostic Outcomes of Tall Cell Variant Papillary Thyroid Cancer: A Meta-Analysis 

    Jalisi, Scharukh; Ainsworth, Tiffiny; LaValley, Michael (SAGE-Hindawi Access to Research, 2010-7-26)
    Objective. To evaluate the prognosis of tall cell variant (TCV) compared to usual variant (UV) papillary thyroid cancer by comparing disease-related mortality and recurrence data from published studies. Methods. Ovid MEDLINE ...
  • Routine HIV Screening in France: Clinical Impact and Cost-Effectiveness 

    Yazdanpanah, Yazdan; Sloan, Caroline E.; Charlois-Ou, Cécile; Le Vu, Stéphane; Semaille, Caroline; Costagliola, Dominique; Pillonel, Josiane; Poullié, Anne-Isabelle; Scemama, Olivier; Deuffic-Burban, Sylvie; Losina, Elena; Walensky, Rochelle P.; Freedberg, Kenneth A.; Paltiel, A. David (Public Library of Science, 2010-10-1)
    BACKGROUND. In France, roughly 40,000 HIV-infected persons are unaware of their HIV infection. Although previous studies have evaluated the cost-effectiveness of routine HIV screening in the United States, differences in ...
  • Effect of Spatial Resolution on Cluster Detection: A Simulation Study 

    Ozonoff, Al; Jeffery, Caroline; Manjourides, Justin; White, Laura Forsberg; Pagano, Marcello (BioMed Central, 2007-11-27)
    BACKGROUND. Aggregation of spatial data is intended to protect privacy, but some effects of aggregation on spatial methods have not yet been quantified. METHODS. We generated 3,000 spatial data sets and evaluated power of ...
  • Genetics Analysis Workshop 16 Problem 2: tTe Framingham Heart Study Data 

    Cupples, L. Adrienne; Heard-Costa, Nancy; Lee, Monica; Atwood, Larry D. (BioMed Central, 2009-12-15)
    Genetic Analysis Workshop 16 (GAW16) Problem 2 presented data from the Framingham Heart Study (FHS), an observational, prospective study of risk factors for cardiovascular disease begun in 1948. Data have been collected ...
  • Method for Mapping Population-Based Case-Control Studies: An Application Using Generalized Additive Models 

    Webster, Thomas; Vieira, Verónica; Weinberg, Janice; Aschengrau, Ann (BioMed Central, 2006-6-9)
    BACKGROUND. Mapping spatial distributions of disease occurrence and risk can serve as a useful tool for identifying exposures of public health concern. Disease registry data are often mapped by town or county of diagnosis ...
  • Population-Based Rates of Revision of Primary Total Hip Arthroplasty: A Systematic Review 

    Corbett, Kelly L.; Losina, Elena; Nti, Akosua A.; Prokopetz, Julian J. Z.; Katz, Jeffrey N. (Public Library of Science, 2010-10-20)
    BACKGROUND. Most research on failure leading to revision total hip arthroplasty (THA) is reported from single centers. We searched PubMed between January 2000 and August 2010 to identify population- or community-based ...
  • Assessing the Performance of a Computer-Based Policy Model of HIV and AIDS 

    Rydzak, Chara E.; Cotich, Kara L.; Sax, Paul E.; Hsu, Heather E.; Wang, Bingxia; Losina, Elena; Freedberg, Kenneth A.; Weinstein, Milton C.; Goldie, Sue J. (Public Library of Science, 2010-9-9)
    BACKGROUND. Model-based analyses, conducted within a decision analytic framework, provide a systematic way to combine information about the natural history of disease and effectiveness of clinical management strategies ...
  • The "ART" of Linkage: Pre-Treatment Loss to Care after HIV Diagnosis at Two PEPFAR Sites in Durban, South Africa 

    Losina, Elena; Bassett, Ingrid V.; Giddy, Janet; Chetty, Senica; Regan, Susan; Walensky, Rochelle P.; Ross, Douglas; Scott, Callie A.; Uhler, Lauren M.; Katz, Jeffrey N.; Holst, Helga; Freedberg, Kenneth A. (Public Library of Science, 2010-3-4)
    BACKGROUND. Although loss to follow-up after antiretroviral therapy (ART) initiation is increasingly recognized, little is known about pre-treatment losses to care (PTLC) after an initial positive HIV test. Our objective ...
  • Caregiving, Metabolic Syndrome Indicators, and 1-year Decline in Walking Speed: Results of Caregiver-SOF 

    Fredman, Lisa; Doros, Gheorghe; Cauley, Jane A.; Hillier, Teresa A.; Hochberg, Marc C. (Oxford University Press, 2010-3-29)
    BACKGROUND Chronic stress may lead to health decline through metabolic syndrome. Thus, persons in stressful caregiving situations who also have more indicators of metabolic syndrome may experience more decline than other ...
  • Patterns of Co-Expression for Protein Complexes by Size in Saccharomyces Cerevisiae 

    Liu, Ching-Ti; Yuan, Shinsheng; Li, Ker-Chau (Nucleic Acids Research, 2009-2)
    Many successful functional studies by gene expression profiling in the literature have led to the perception that profile similarity is likely to imply functional association. But how true is the converse of the above ...
  • Transmissibility of the Influenza Virus in the 1918 Pandemic 

    White, Laura Forsberg; Pagano, Marcello (Public Library of Science, 2008-1-30)
    BACKGROUND. With a heightened increase in concern for an influenza pandemic we sought to better understand the 1918 Influenza pandemic, the most devastating epidemic of the previous century. METHODOLOGY/PRINCIPAL FINDINGS. ...
  • Genetic Analysis Workshop 16: Strategies for Genome-Wide Association Study Analyses 

    Cupples, L. Adrienne; Beyene, Joseph; Bickeböller, Heike; Daw, E. Warwick; Fallin, M. Daniele; Gauderman, W. James; Ghosh, Saurabh; Goode, Ellen L.; Hauser, Elizabeth R.; Hinrichs, Anthony; Kent, Jack W.; Martin, Lisa J.; Martinez, Maria; Neuman, Rosalind J.; Province, Michael; Szymczak, Silke; Wilcox, Marsha A.; Ziegler, Andreas; MacCluer, Jean W.; Almasy, Laura (BioMed Central, 2009-12-15)
  • Forty-Three Loci Associated with Plasma Lipoprotein Size, Concentration, and Cholesterol Content in Genome-Wide Analysis 

    Chasman, Daniel I.; Paré, Guillaume; Mora, Samia; Hopewell, Jemma C.; Peloso, Gina; Clarke, Robert; Cupples, L. Adrienne; Hamsten, Anders; Kathiresan, Sekar; Mälarstig, Anders; Ordovas, José M.; Ripatti, Samuli; Parker, Alex N.; Miletich, Joseph P.; Ridker, Paul M. (Public Library of Science, 2009-11-20)
    While conventional LDL-C, HDL-C, and triglyceride measurements reflect aggregate properties of plasma lipoprotein fractions, NMR-based measurements more accurately reflect lipoprotein particle concentrations according to ...
  • Towards Equitable Access to Medicines for the Rural Poor: Analyses of Insurance Claims Reveal Rural Pharmacy Initiative Triggers Price Competition in Kyrgyzstan 

    Waning, Brenda; Maddix, Jason; Tripodis, Yorghos; Laing, Richard; Leufkens, Hubert GM; Gokhale, Manjusha (BioMed Central, 2009-12-14)
    BACKGROUND. A rural pharmacy initiative (RPI) designed to increase access to medicines in rural Kyrgyzstan created a network of 12 pharmacies using a revolving drug fund mechanism in 12 villages where no pharmacies previously ...
  • Bayesian Approaches to Reverse Engineer Cellular Systems: A Simulation Study on Nonlinear Gaussian Networks 

    Ferrazzi, Fulvia; Sebastiani, Paola; Ramoni, Marco F; Bellazzi, Riccardo (BioMed Central, 2007-5-24)
    BACKGROUND. Reverse engineering cellular networks is currently one of the most challenging problems in systems biology. Dynamic Bayesian networks (DBNs) seem to be particularly suitable for inferring relationships between ...
  • Screening Large-Scale Association Study Data: Exploiting Interactions Using Random Forests 

    Lunetta, Kathryn L; Hayward, L Brooke; Segal, Jonathan; Van Eerdewegh, Paul (BioMed Central, 2004-12-10)
    BACKGROUND. Genome-wide association studies for complex diseases will produce genotypes on hundreds of thousands of single nucleotide polymorphisms (SNPs). A logical first approach to dealing with massive numbers of SNPs ...
  • Incorporating Biological Knowledge in the Search for Gene × Gene Interaction in Genome-Wide Association Studies 

    Manning, Alisa K; Ngwa, Julius Suh; Hendricks, Audrey E; Liu, Ching-Ti; Johnson, Andrew D; Dupuis, Josée; Cupples, L Adrienne (BioMed Central, 2009-12-15)
    We sought to find significant gene × gene interaction in a genome-wide association analysis of rheumatoid arthritis (RA) by performing pair-wise tests of interaction among collections of single-nucleotide polymorphisms ...
  • Identification of Polymorphisms Explaining a Linkage Signal: Application to the GAW14 Simulated Data 

    Chen, Ming-Huei; Van Eerdewegh, Paul; Dupuis, Josée (BioMed Central, 2005-12-30)
    We applied three approaches for the identification of polymorphisms explaining the linkage evidence to the Genetic Analysis Workshop 14 simulated data: 1) the genotype-IBD sharing test (GIST); 2) an approach suggested by ...
  • Mapping Complex Traits Using Random Forests 

    Bureau, Alexandre; Dupuis, Josée; Hayward, Brooke; Falls, Kathleen; Van Eerdewegh, Paul (BioMed Central, 2003-12-31)
    Random Forest is a prediction technique based on growing trees on bootstrap samples of data, in conjunction with a random selection of explanatory variables to define the best split at each node. In the case of a quantitative ...

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