URI: http://hdl.handle.net/2144/1019

Recently Added

  • An Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis-Related Traits 

    Hsu, Yi-Hsiang; Zillikens, M. Carola; Wilson, Scott G.; Farber, Charles R.; Demissie, Serkalem; Soranzo, Nicole; Bianchi, Estelle N.; Grundberg, Elin; Liang, Liming; Richards, J. Brent; Estrada, Karol; Zhou, Yanhua; van Nas, Atila; Moffatt, Miriam F.; Zhai, Guangju; Hofman, Albert; van Meurs, Joyce B.; Pols, Huibert A. P.; Price, Roger I.; Nilsson, Olle; Pastinen, Tomi; Cupples, L. Adrienne; Lusis, Aldons J.; Schadt, Eric E.; Ferrari, Serge; Uitterlinden, André G.; Rivadeneira, Fernando; Spector, Timothy D.; Karasik, David; Kiel, Douglas P. (Public Library of Science, 2010-6-10)
    Osteoporosis is a complex disorder and commonly leads to fractures in elderly persons. Genome-wide association studies (GWAS) have become an unbiased approach to identify variations in the genome that potentially affect ...
  • A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels 

    Richards, J. Brent; Waterworth, Dawn; O'Rahilly, Stephen; Hivert, Marie-France; Loos, Ruth J. F.; Perry, John R. B.; Tanaka, Toshiko; Timpson, Nicholas John; Semple, Robert K.; Soranzo, Nicole; Song, Kijoung; Rocha, Nuno; Grundberg, Elin; Dupuis, Josée; Florez, Jose C.; Langenberg, Claudia; Prokopenko, Inga; Saxena, Richa; Sladek, Robert; Aulchenko, Yurii; Evans, David; Waeber, Gerard; Erdmann, Jeanette; Burnett, Mary-Susan; Sattar, Naveed; Devaney, Joseph; Willenborg, Christina; Hingorani, Aroon; Witteman, Jaquelin C. M.; Vollenweider, Peter; Glaser, Beate; Hengstenberg, Christian; Ferrucci, Luigi; Melzer, David; Stark, Klaus; Deanfield, John; Winogradow, Janina; Grassl, Martina; Hall, Alistair S.; Egan, Josephine M.; Thompson, John R.; Ricketts, Sally L.; König, Inke R.; Reinhard, Wibke; Grundy, Scott; Wichmann, H-Erich; Barter, Phil; Mahley, Robert; Kesaniemi, Y. Antero; Rader, Daniel J.; Reilly, Muredach P.; Epstein, Stephen E.; Stewart, Alexandre F. R.; Van Duijn, Cornelia M.; Schunkert, Heribert; Burling, Keith; Deloukas, Panos; Pastinen, Tomi; Samani, Nilesh J.; McPherson, Ruth; Davey Smith, George; Frayling, Timothy M.; Wareham, Nicholas J.; Meigs, James B.; Mooser, Vincent; Spector, Tim D. (Public Library of Science, 2009-12-11)
    The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed 3 genome-wide association studies for ...
  • Routine HIV Screening in France: Clinical Impact and Cost-Effectiveness 

    Yazdanpanah, Yazdan; Sloan, Caroline E.; Charlois-Ou, Cécile; Le Vu, Stéphane; Semaille, Caroline; Costagliola, Dominique; Pillonel, Josiane; Poullié, Anne-Isabelle; Scemama, Olivier; Deuffic-Burban, Sylvie; Losina, Elena; Walensky, Rochelle P.; Freedberg, Kenneth A.; Paltiel, A. David (Public Library of Science, 2010-10-1)
    BACKGROUND. In France, roughly 40,000 HIV-infected persons are unaware of their HIV infection. Although previous studies have evaluated the cost-effectiveness of routine HIV screening in the United States, differences in ...
  • Does Modality of Survey Administration Impact Data Quality: Audio Computer Assisted Self Interview (ACASI) Versus Self-Administered Pen and Paper? 

    Reichmann, William M.; Losina, Elena; Seage, George R.; Arbelaez, Christian; Safren, Steven A.; Katz, Jeffrey N.; Hetland, Adam; Walensky, Rochelle P. (Public Library of Science, 2010-1-15)
    BACKGROUND. In the context of a randomized controlled trial (RCT) on HIV testing in the emergency department (ED) setting, we evaluated preferences for survey modality and data quality arising from each modality. METHODS. ...
  • Population-Based Rates of Revision of Primary Total Hip Arthroplasty: A Systematic Review 

    Corbett, Kelly L.; Losina, Elena; Nti, Akosua A.; Prokopetz, Julian J. Z.; Katz, Jeffrey N. (Public Library of Science, 2010-10-20)
    BACKGROUND. Most research on failure leading to revision total hip arthroplasty (THA) is reported from single centers. We searched PubMed between January 2000 and August 2010 to identify population- or community-based ...
  • Transmissibility of the Influenza Virus in the 1918 Pandemic 

    White, Laura Forsberg; Pagano, Marcello (Public Library of Science, 2008-1-30)
    BACKGROUND. With a heightened increase in concern for an influenza pandemic we sought to better understand the 1918 Influenza pandemic, the most devastating epidemic of the previous century. METHODOLOGY/PRINCIPAL FINDINGS. ...
  • Offspring's Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm 

    Kimura, Masayuki; Cherkas, Lynn F; Kato, Bernet S; Demissie, Serkalem; Hjelmborg, Jacob B; Brimacombe, Michael; Cupples, Adrienne; Hunkin, Janice L; Gardner, Jefferey P; Lu, Xiaobin; Cao, Xiaojian; Sastrasinh, Malinee; Province, Michael A; Hunt, Steven C; Christensen, Kaare; Levy, Daniel; Spector, Tim D; Aviv, Abraham (Public Library of Science, 2008-2-15)
    Leukocyte telomere length (LTL) is a complex genetic trait. It shortens with age and is associated with a host of aging-related disorders. Recent studies have observed that offspring of older fathers have longer LTLs. We ...
  • Forty-Three Loci Associated with Plasma Lipoprotein Size, Concentration, and Cholesterol Content in Genome-Wide Analysis 

    Chasman, Daniel I.; Paré, Guillaume; Mora, Samia; Hopewell, Jemma C.; Peloso, Gina; Clarke, Robert; Cupples, L. Adrienne; Hamsten, Anders; Kathiresan, Sekar; Mälarstig, Anders; Ordovas, José M.; Ripatti, Samuli; Parker, Alex N.; Miletich, Joseph P.; Ridker, Paul M. (Public Library of Science, 2009-11-20)
    While conventional LDL-C, HDL-C, and triglyceride measurements reflect aggregate properties of plasma lipoprotein fractions, NMR-based measurements more accurately reflect lipoprotein particle concentrations according to ...
  • Genetic Analysis Workshop 16: Strategies for Genome-Wide Association Study Analyses 

    Cupples, L. Adrienne; Beyene, Joseph; Bickeböller, Heike; Daw, E. Warwick; Fallin, M. Daniele; Gauderman, W. James; Ghosh, Saurabh; Goode, Ellen L.; Hauser, Elizabeth R.; Hinrichs, Anthony; Kent, Jack W.; Martin, Lisa J.; Martinez, Maria; Neuman, Rosalind J.; Province, Michael; Szymczak, Silke; Wilcox, Marsha A.; Ziegler, Andreas; MacCluer, Jean W.; Almasy, Laura (BioMed Central, 2009-12-15)
  • Method for Mapping Population-Based Case-Control Studies: An Application Using Generalized Additive Models 

    Webster, Thomas; Vieira, Verónica; Weinberg, Janice; Aschengrau, Ann (BioMed Central, 2006-6-9)
    BACKGROUND. Mapping spatial distributions of disease occurrence and risk can serve as a useful tool for identifying exposures of public health concern. Disease registry data are often mapped by town or county of diagnosis ...
  • Genetic Analysis Workshop 15: Gene Expression Analysis and Approaches to Detecting Multiple Functional Loci 

    Cordell, Heather J.; de Andrade, Mariza; Babron, Marie-Claude; Bartlett, Christopher W.; Beyene, Joseph; Bickeböller, Heike; Culverhouse, Robert; Cupples, L Adrienne; Daw, E. Warwick; Dupuis, Josée; Falk, Catherine T.; Ghosh, Saurabh; Goddard, Katrina A.; Goode, Ellen L.; Hauser, Elizabeth R.; Martin, Lisa J.; Martinez, Maria; North, Kari E.; Saccone, Nancy L.; Schmidt, Silke; Tapper, William; Thomas, Duncan; Tritchler, David; Vieland, Veronica J.; Wijsman, Ellen M.; Wilcox, Marsha A.; Witte, John S.; Yang, Qiong; Ziegler, Andreas; Almasy, Laura; MacCluer, Jean W. (BioMed Central, 2007-12-18)
  • Effect of Spatial Resolution on Cluster Detection: A Simulation Study 

    Ozonoff, Al; Jeffery, Caroline; Manjourides, Justin; White, Laura Forsberg; Pagano, Marcello (BioMed Central, 2007-11-27)
    BACKGROUND. Aggregation of spatial data is intended to protect privacy, but some effects of aggregation on spatial methods have not yet been quantified. METHODS. We generated 3,000 spatial data sets and evaluated power of ...
  • The "ART" of Linkage: Pre-Treatment Loss to Care after HIV Diagnosis at Two PEPFAR Sites in Durban, South Africa 

    Losina, Elena; Bassett, Ingrid V.; Giddy, Janet; Chetty, Senica; Regan, Susan; Walensky, Rochelle P.; Ross, Douglas; Scott, Callie A.; Uhler, Lauren M.; Katz, Jeffrey N.; Holst, Helga; Freedberg, Kenneth A. (Public Library of Science, 2010-3-4)
    BACKGROUND. Although loss to follow-up after antiretroviral therapy (ART) initiation is increasingly recognized, little is known about pre-treatment losses to care (PTLC) after an initial positive HIV test. Our objective ...
  • Selective Disruption of the Cerebral Neocortex in Alzheimer's Disease 

    Desikan, Rahul S.; Sabuncu, Mert R.; Schmansky, Nicholas J.; Reuter, Martin; Cabral, Howard J.; Hess, Christopher P.; Weiner, Michael W.; Biffi, Alessandro; Anderson, Christopher D.; Rosand, Jonathan; Salat, David H.; Kemper, Thomas L.; Dale, Anders M.; Sperling, Reisa A.; Fischl, Bruce (Public Library of Science, 2010-9-23)
    BACKGROUND. Alzheimer's disease (AD) and its transitional state mild cognitive impairment (MCI) are characterized by amyloid plaque and tau neurofibrillary tangle (NFT) deposition within the cerebral neocortex and neuronal ...
  • Genome-Wide Association Studies of Serum Magnesium, Potassium, and Sodium Concentrations Identify Six Loci Influencing Serum Magnesium Levels 

    Meyer, Tamra E.; Verwoert, Germaine C.; Hwang, Shih-Jen; Glazer, Nicole L.; Smith, Albert V.; van Rooij, Frank J. A.; Ehret, Georg B.; Boerwinkle, Eric; Felix, Janine F.; Leak, Tennille S.; Harris, Tamara B.; Yang, Qiong; Dehghan, Abbas; Aspelund, Thor; Katz, Ronit; Homuth, Georg; Kocher, Thomas; Rettig, Rainer; Ried, Janina S.; Gieger, Christian; Prucha, Hanna; Pfeufer, Arne; Meitinger, Thomas; Coresh, Josef; Hofman, Albert; Sarnak, Mark J.; Chen, Yii-Der Ida; Uitterlinden, André G.; Chakravarti, Aravinda; Psaty, Bruce M.; van Duijn, Cornelia M.; Kao, W. H. Linda; Witteman, Jacqueline C. M.; Gudnason, Vilmundur; Siscovick, David S.; Fox, Caroline S.; Köttgen, Anna (Public Library of Science, 2010-8-5)
    Magnesium, potassium, and sodium, cations commonly measured in serum, are involved in many physiological processes including energy metabolism, nerve and muscle function, signal transduction, and fluid and blood pressure ...
  • Cost-Effectiveness of Preventing Loss to Follow-up in HIV Treatment Programs: A Côte d'Ivoire Appraisal 

    Losina, Elena; Touré, Hapsatou; Uhler, Lauren M.; Anglaret, Xavier; Paltiel, A. David; Balestre, Eric; Walensky, Rochelle P.; Messou, Eugène; Weinstein, Milton C.; Dabis, François; Freedberg, Kenneth A. (Public Library of Science, 2009-10-27)
    Based on data from West Africa, Elena Losina and colleagues predict that interventions to reduce dropout rates from HIV treatment programs (such as eliminating copayments) will be cost-effective. BACKGROUND. Data from ...
  • Joint Modeling of Linkage and Association Using Affected Sib-Pair Data 

    Chen, Ming-Huei; Cui, Jing; Guo, Chao-Yu; Cupples, L Adrienne; Van Eerdewegh, Paul; Dupuis, Josée; Yang, Qiong (BioMed Central, 2007-12-18)
    There has been a growing interest in developing strategies for identifying single-nucleotide polymorphisms (SNPs) that explain a linkage signal by joint modeling of linkage and association. We compare several existing ...
  • A Power Comparison of Generalized Additive Models and the Spatial Scan Statistic in a Case-Control Setting 

    Young, Robin L; Weinberg, Janice; Vieira, Verónica; Ozonoff, Al; Webster, Thomas F (2010-7-19)
    BACKGROUND. A common, important problem in spatial epidemiology is measuring and identifying variation in disease risk across a study region. In application of statistical methods, the problem has two parts. First, spatial ...
  • Spatial Analysis of Learning and Developmental Disorders in Upper Cape Cod, Massachusetts Using Generalized Additive Models 

    Hoffman, Kate; Webster, Thomas F; Weinberg, Janice M; Aschengrau, Ann; Janulewicz, Patricia A; White, Roberta F; Vieira, Verónica M (BioMed Central, 2010-2-12)
    The spatial variability of three indicators of learning and developmental disability (LDD) was assessed for Cape Cod, Massachusetts. Maternal reports of receiving special education services, attention deficit hyperactivity ...
  • A Multilevel Non-Hierarchical Study of Birth Weight and Socioeconomic Status 

    Young, Robin L; Weinberg, Janice; Vieira, Verónica; Aschengrau, Ann; Webster, Thomas F (BioMed Central, 2010-7-9)
    BACKGROUND. It is unclear whether the socioeconomic status (SES) of the community of residence has a substantial association with infant birth weight. We used multilevel models to examine associations of birth weight with ...

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