URI: http://hdl.handle.net/2144/1019

Recently Added

  • The "ART" of Linkage: Pre-Treatment Loss to Care after HIV Diagnosis at Two PEPFAR Sites in Durban, South Africa 

    Losina, Elena; Bassett, Ingrid V.; Giddy, Janet; Chetty, Senica; Regan, Susan; Walensky, Rochelle P.; Ross, Douglas; Scott, Callie A.; Uhler, Lauren M.; Katz, Jeffrey N.; Holst, Helga; Freedberg, Kenneth A. (Public Library of Science, 2010-3-4)
    BACKGROUND. Although loss to follow-up after antiretroviral therapy (ART) initiation is increasingly recognized, little is known about pre-treatment losses to care (PTLC) after an initial positive HIV test. Our objective ...
  • Selective Disruption of the Cerebral Neocortex in Alzheimer's Disease 

    Desikan, Rahul S.; Sabuncu, Mert R.; Schmansky, Nicholas J.; Reuter, Martin; Cabral, Howard J.; Hess, Christopher P.; Weiner, Michael W.; Biffi, Alessandro; Anderson, Christopher D.; Rosand, Jonathan; Salat, David H.; Kemper, Thomas L.; Dale, Anders M.; Sperling, Reisa A.; Fischl, Bruce (Public Library of Science, 2010-9-23)
    BACKGROUND. Alzheimer's disease (AD) and its transitional state mild cognitive impairment (MCI) are characterized by amyloid plaque and tau neurofibrillary tangle (NFT) deposition within the cerebral neocortex and neuronal ...
  • Effect of Spatial Resolution on Cluster Detection: A Simulation Study 

    Ozonoff, Al; Jeffery, Caroline; Manjourides, Justin; White, Laura Forsberg; Pagano, Marcello (BioMed Central, 2007-11-27)
    BACKGROUND. Aggregation of spatial data is intended to protect privacy, but some effects of aggregation on spatial methods have not yet been quantified. METHODS. We generated 3,000 spatial data sets and evaluated power of ...
  • Method for Mapping Population-Based Case-Control Studies: An Application Using Generalized Additive Models 

    Webster, Thomas; Vieira, Verónica; Weinberg, Janice; Aschengrau, Ann (BioMed Central, 2006-6-9)
    BACKGROUND. Mapping spatial distributions of disease occurrence and risk can serve as a useful tool for identifying exposures of public health concern. Disease registry data are often mapped by town or county of diagnosis ...
  • Genetic Analysis Workshop 16: Strategies for Genome-Wide Association Study Analyses 

    Cupples, L. Adrienne; Beyene, Joseph; Bickeböller, Heike; Daw, E. Warwick; Fallin, M. Daniele; Gauderman, W. James; Ghosh, Saurabh; Goode, Ellen L.; Hauser, Elizabeth R.; Hinrichs, Anthony; Kent, Jack W.; Martin, Lisa J.; Martinez, Maria; Neuman, Rosalind J.; Province, Michael; Szymczak, Silke; Wilcox, Marsha A.; Ziegler, Andreas; MacCluer, Jean W.; Almasy, Laura (BioMed Central, 2009-12-15)
  • Genetic Analysis Workshop 15: Gene Expression Analysis and Approaches to Detecting Multiple Functional Loci 

    Cordell, Heather J.; de Andrade, Mariza; Babron, Marie-Claude; Bartlett, Christopher W.; Beyene, Joseph; Bickeböller, Heike; Culverhouse, Robert; Cupples, L Adrienne; Daw, E. Warwick; Dupuis, Josée; Falk, Catherine T.; Ghosh, Saurabh; Goddard, Katrina A.; Goode, Ellen L.; Hauser, Elizabeth R.; Martin, Lisa J.; Martinez, Maria; North, Kari E.; Saccone, Nancy L.; Schmidt, Silke; Tapper, William; Thomas, Duncan; Tritchler, David; Vieland, Veronica J.; Wijsman, Ellen M.; Wilcox, Marsha A.; Witte, John S.; Yang, Qiong; Ziegler, Andreas; Almasy, Laura; MacCluer, Jean W. (BioMed Central, 2007-12-18)
  • Forty-Three Loci Associated with Plasma Lipoprotein Size, Concentration, and Cholesterol Content in Genome-Wide Analysis 

    Chasman, Daniel I.; Paré, Guillaume; Mora, Samia; Hopewell, Jemma C.; Peloso, Gina; Clarke, Robert; Cupples, L. Adrienne; Hamsten, Anders; Kathiresan, Sekar; Mälarstig, Anders; Ordovas, José M.; Ripatti, Samuli; Parker, Alex N.; Miletich, Joseph P.; Ridker, Paul M. (Public Library of Science, 2009-11-20)
    While conventional LDL-C, HDL-C, and triglyceride measurements reflect aggregate properties of plasma lipoprotein fractions, NMR-based measurements more accurately reflect lipoprotein particle concentrations according to ...
  • A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels 

    Richards, J. Brent; Waterworth, Dawn; O'Rahilly, Stephen; Hivert, Marie-France; Loos, Ruth J. F.; Perry, John R. B.; Tanaka, Toshiko; Timpson, Nicholas John; Semple, Robert K.; Soranzo, Nicole; Song, Kijoung; Rocha, Nuno; Grundberg, Elin; Dupuis, Josée; Florez, Jose C.; Langenberg, Claudia; Prokopenko, Inga; Saxena, Richa; Sladek, Robert; Aulchenko, Yurii; Evans, David; Waeber, Gerard; Erdmann, Jeanette; Burnett, Mary-Susan; Sattar, Naveed; Devaney, Joseph; Willenborg, Christina; Hingorani, Aroon; Witteman, Jaquelin C. M.; Vollenweider, Peter; Glaser, Beate; Hengstenberg, Christian; Ferrucci, Luigi; Melzer, David; Stark, Klaus; Deanfield, John; Winogradow, Janina; Grassl, Martina; Hall, Alistair S.; Egan, Josephine M.; Thompson, John R.; Ricketts, Sally L.; König, Inke R.; Reinhard, Wibke; Grundy, Scott; Wichmann, H-Erich; Barter, Phil; Mahley, Robert; Kesaniemi, Y. Antero; Rader, Daniel J.; Reilly, Muredach P.; Epstein, Stephen E.; Stewart, Alexandre F. R.; Van Duijn, Cornelia M.; Schunkert, Heribert; Burling, Keith; Deloukas, Panos; Pastinen, Tomi; Samani, Nilesh J.; McPherson, Ruth; Davey Smith, George; Frayling, Timothy M.; Wareham, Nicholas J.; Meigs, James B.; Mooser, Vincent; Spector, Tim D. (Public Library of Science, 2009-12-11)
    The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed 3 genome-wide association studies for ...
  • Towards Equitable Access to Medicines for the Rural Poor: Analyses of Insurance Claims Reveal Rural Pharmacy Initiative Triggers Price Competition in Kyrgyzstan 

    Waning, Brenda; Maddix, Jason; Tripodis, Yorghos; Laing, Richard; Leufkens, Hubert GM; Gokhale, Manjusha (BioMed Central, 2009-12-14)
    BACKGROUND. A rural pharmacy initiative (RPI) designed to increase access to medicines in rural Kyrgyzstan created a network of 12 pharmacies using a revolving drug fund mechanism in 12 villages where no pharmacies previously ...
  • Bayesian Approaches to Reverse Engineer Cellular Systems: A Simulation Study on Nonlinear Gaussian Networks 

    Ferrazzi, Fulvia; Sebastiani, Paola; Ramoni, Marco F; Bellazzi, Riccardo (BioMed Central, 2007-5-24)
    BACKGROUND. Reverse engineering cellular networks is currently one of the most challenging problems in systems biology. Dynamic Bayesian networks (DBNs) seem to be particularly suitable for inferring relationships between ...
  • Screening Large-Scale Association Study Data: Exploiting Interactions Using Random Forests 

    Lunetta, Kathryn L; Hayward, L Brooke; Segal, Jonathan; Van Eerdewegh, Paul (BioMed Central, 2004-12-10)
    BACKGROUND. Genome-wide association studies for complex diseases will produce genotypes on hundreds of thousands of single nucleotide polymorphisms (SNPs). A logical first approach to dealing with massive numbers of SNPs ...
  • Incorporating Biological Knowledge in the Search for Gene × Gene Interaction in Genome-Wide Association Studies 

    Manning, Alisa K; Ngwa, Julius Suh; Hendricks, Audrey E; Liu, Ching-Ti; Johnson, Andrew D; Dupuis, Josée; Cupples, L Adrienne (BioMed Central, 2009-12-15)
    We sought to find significant gene × gene interaction in a genome-wide association analysis of rheumatoid arthritis (RA) by performing pair-wise tests of interaction among collections of single-nucleotide polymorphisms ...
  • Identification of Polymorphisms Explaining a Linkage Signal: Application to the GAW14 Simulated Data 

    Chen, Ming-Huei; Van Eerdewegh, Paul; Dupuis, Josée (BioMed Central, 2005-12-30)
    We applied three approaches for the identification of polymorphisms explaining the linkage evidence to the Genetic Analysis Workshop 14 simulated data: 1) the genotype-IBD sharing test (GIST); 2) an approach suggested by ...
  • Mapping Complex Traits Using Random Forests 

    Bureau, Alexandre; Dupuis, Josée; Hayward, Brooke; Falls, Kathleen; Van Eerdewegh, Paul (BioMed Central, 2003-12-31)
    Random Forest is a prediction technique based on growing trees on bootstrap samples of data, in conjunction with a random selection of explanatory variables to define the best split at each node. In the case of a quantitative ...
  • Description of the Framingham Heart Study Data for Genetic Analysis Workshop 13 

    Cupples, L Adrienne; Yang, Qiong; Demissie, Serkalem; Copenhafer, Donna; Levy, Daniel (BioMed Central, 2003-12-31)
  • Joint Modeling of Linkage and Association Using Affected Sib-Pair Data 

    Chen, Ming-Huei; Cui, Jing; Guo, Chao-Yu; Cupples, L Adrienne; Van Eerdewegh, Paul; Dupuis, Josée; Yang, Qiong (BioMed Central, 2007-12-18)
    There has been a growing interest in developing strategies for identifying single-nucleotide polymorphisms (SNPs) that explain a linkage signal by joint modeling of linkage and association. We compare several existing ...
  • Handling Linkage Disequilibrium in Qualitative Trait Linkage Analysis Using Dense SNPs: A Two-Step Strategy 

    Cho, Kelly; Dupuis, Josée (BioMed Central, 2009-8-10)
    BACKGROUND. In affected sibling pair linkage analysis, the presence of linkage disequilibrium (LD) has been shown to lead to overestimation of the number of alleles shared identity-by-descent (IBD) among sibling pairs when ...
  • Principal-Component-Based Population Structure Adjustment in the North American Rheumatoid Arthritis Consortium Data: Impact of Single-Nucleotide Polymorphism Set and Analysis Method 

    Peloso, Gina M; Timofeev, Nadia; Lunetta, Kathryn L (BioMed Central, 2009-12-15)
    Population structure occurs when a sample is composed of individuals with different ancestries and can result in excess type I error in genome-wide association studies. Genome-wide principal-component analysis (PCA) has ...
  • Genome-Wide Association and Linkage Analysis of Quantitative Traits: Comparison pf Likelihood-Ratio Test and Conditional Score Statistic 

    Hendricks, Audrey E; Zhu, Yanyan; Dupuis, Josée (BioMed Central, 2009-12-15)
    Over the past decade, genetic analysis has shifted from linkage studies, which identify broad regions containing putative trait loci, to genome-wide association studies, which detect the association of a marker with a ...
  • Caregiving, Metabolic Syndrome Indicators, and 1-year Decline in Walking Speed: Results of Caregiver-SOF 

    Fredman, Lisa; Doros, Gheorghe; Cauley, Jane A.; Hillier, Teresa A.; Hochberg, Marc C. (Oxford University Press, 2010-3-29)
    BACKGROUND Chronic stress may lead to health decline through metabolic syndrome. Thus, persons in stressful caregiving situations who also have more indicators of metabolic syndrome may experience more decline than other ...

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