The complement-fixing properties of sensitizing and neutralizing antibodies in the blood of allergic human subjects.
Follensby, Edna Mildred
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In 1921 transfer of sensitivity to the skin of a normal, nonallergic, human subject was effected by the endermal injection of a small amount of serum obtained from a patient sensitive to fish. This method of local passive transfer, the Prausnitz-Kustner technic, became the accepted method of detecting the skin-sensitizing antibody present in the serum of some supersensitive, or allergic, individuals. Later the term "atopic reagin" was suggested to designate this type of antibody. The studies of many investigators have provided information concerning the occurrence and characteristics of reaginic antibody. Serum of all allergic subjects does not contain reagin, and it has not been found in the spinal fluid and cord blood of subjects having reaginic sera of high titer. There is variation in the sensitizing capacity of serum from different subjects, and, also, in different samples from the same subject. Reaginic sera may retain their sensitizing power for long periods, or, in some cases, may lose it quickly. Studies by several investigators have shown that although there are differences among recipients in the acceptance of passive transfer, entirely non-receptive recipients are uncommon. Local passive sensitiveness has been found to persist for at least four weeks. Passive transfer of sensitivity for many difference substances has been observed, but not for all substances causing supersensitiveness in man. [TRUNCATED]
Thesis (Ph.D.)--Boston University