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dc.contributor.authorCruz, Frederic Anthony Siloen_US
dc.date.accessioned2015-08-04T15:33:38Z
dc.date.available2015-08-04T15:33:38Z
dc.date.issued2013
dc.date.submitted2013
dc.identifier.other
dc.identifier.urihttps://hdl.handle.net/2144/12079
dc.descriptionThesis (M.S.)--Boston Universityen_US
dc.description.abstractThe following thesis proposes the question if current scientific data supports the hypothesis that an acute myocardial infarction, not identified by gross symptoms, can be visualized by using apoptotic signaling biomarkers as a diagnostic tool to complement a post-mortem autopsy. The biochemistry and mechanisms of irreversible cellular death is presented and supported through published experimental, clinical and case studies. Furthermore, the aforesaid biomarkers have been observed in the cardiac myocyte in elevated levels associated with hypoxic ischemia. In addition, the physical characteristic of DNA fragmentation is addressed to visualize apoptotic injury due to hypoxic ischemic conditions. Although the quality of evidence lacked published data to suggest one immunochemical staining method positively identifies a myocardial infarction, there is adequate data to suggest that a combination of staining methods can be utilized as a tool to positively identify and diagnose an acute myocardial infarction.en_US
dc.language.isoen_US
dc.publisherBoston Universityen_US
dc.titleFeatures or forensic pathology in sudden cardiac death: are there histologic indicators of acute myocardial ischemia?en_US
dc.typeThesis/Dissertationen_US
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineBiomedical Forensic Sciencesen_US
etd.degree.grantorBoston Universityen_US


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