The role of head traume and concussions in producing chronic traumatic encephalopathy: analysis of risk factores, diagnosis, treatment, and prevention

Abstract

Traumatic brain injuries (TBIs) have become a focal point for discussion in the media today. They are an unfortunate part of many recreational activities and military participation. The long-term effects of concussions and other types of mild traumatic brain injury (mTBI) are becoming increasingly evident. It appears that they can contribute to the development of certain neurodegenerative diseases later in life, and of particular interest is chronic traumatic encephalopathy (CTE). CTE is a progressive tauopathy characterized by a variety of cognitive and behavioral changes, which is correlated with a history of repetitive brain trauma. This thesis provides a review of the pertinent literature in attempt to link the development of CTE to the neurophysiological changes associated with concussions and mTBI by providing an in-depth analysis of both concussions and CTE. However, even with the current evidence, prospective studies will be necessary to gain a better understanding of the disorder.