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dc.contributor.authorLinson, Elyse A.en_US
dc.date.accessioned2015-08-04T15:56:20Z
dc.date.available2015-08-04T15:56:20Z
dc.date.issued2013
dc.date.submitted2013
dc.identifier.other
dc.identifier.urihttps://hdl.handle.net/2144/12149
dc.descriptionThesis (M.A.)--Boston Universityen_US
dc.description.abstractThis thesis examines the underlying mechanisms causing the severe and often debilitating symptoms associated with both Irritable Bowel Syndrome and Inflammatory Bowel Disease. These disorders are characterized by, abdominal pain, bloating, constipation and diarrhea, and the symptoms are often intermittent. The variable onset and offset of symptoms suggests that periodic fluctuations in body state or signaling may play a role in the etiology and presentation of symptoms. This thesis proposes that the actions of the main intestinal hormones and their interactions with other hormones such as estrogen and progesterone may explain the oscillatory nature of the symptomatology. Spikes in the hormone progesterone may induce IBS-like symptoms such as cramping and constipation thereby representing a potential mediator of IBS symptoms. Evaluating the hormone progesterone’s role in IBS and IBD may create a new target for therapeutic treatments. Moreover, hormonal-based therapy represents a potential means to treat the cause, rather than just the symptoms of IBS and IBD.en_US
dc.language.isoen_US
dc.publisherBoston Universityen_US
dc.titleThe Interplay between Hormones and Irritable Bowel Diseaseen_US
dc.typeThesis/Dissertationen_US
etd.degree.nameMaster of Artsen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


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