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dc.contributor.authorSayeed, Sabinaen_US
dc.date.accessioned2015-08-04T16:03:12Z
dc.date.available2015-08-04T16:03:12Z
dc.date.issued2013
dc.date.submitted2013
dc.identifier.other
dc.identifier.urihttps://hdl.handle.net/2144/12215
dc.descriptionThesis (M.A.)--Boston Universityen_US
dc.description.abstractIt has long been known that thyroid hormones (TH) are essential for normal growth, development and cell metabolism. Studies have also shown that topical TH application can increase epidermal cell proliferation and accelerate the process of cutaneous wound healing. Despite these promising results, few researchers have examined the mechanisms and mediators through which TH may exert its effects on skin cells. In this study, human fibroblasts were stimulated with increasing triiodothyronine (T3) concentrations. A western blot was then conducted on the stimulated cell samples to determine whether two key growth factors – epidermal growth factor (EGF) and fibroblast growth factor (FGF-7) – that have been implicated in wound healing were upregulated due to topical T3 stimulation. It was found that while EGF (indirectly detected via the presence of the epidermal growth factor receptor (EGFR)) trended towards being upregulated at higher T3 concentrations, no such effect was observed with FGF-7. It was therefore determined that the EGF pathway may be an important mechanism through which TH exerts its effects on human fibroblasts and the process of cutaneous wound healing.en_US
dc.language.isoen_US
dc.publisherBoston Universityen_US
dc.titleThe effects of topical thyroid hormone application on growth factor expression in human fibroblastsen_US
dc.typeThesis/Dissertationen_US
etd.degree.nameMaster of Artsen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


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