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dc.contributor.authorZachariah, Roshinien_US
dc.date.accessioned2015-08-04T16:07:16Z
dc.date.available2015-08-04T16:07:16Z
dc.date.issued2013en_US
dc.date.submitted2013en_US
dc.identifier.otheren_US
dc.identifier.urihttps://hdl.handle.net/2144/12252
dc.descriptionThesis (M.A.)--Boston Universityen_US
dc.description.abstractThis thesis examines the connection between epithelial to mesenchymal transition (EMT) and cancer stem cells (CSC) in solid tumors. Epithelial to mesenchymal transition describes the conversion of cancer cells from an adherent, differentiated, and polar phenotype (epithelial) to a motile, plastic, and apolar phenotype (mesenchymal). EMT is correlated with metastasis; EMT is usually measured by QRT-PCR or immunohistochemistry. Cancer stem cells are thought to be responsible for metastasis and recurrence. They have been found in almost all solid tumors and cancer stem cell-enriched populations are detectable using flow cytometry. EMT and cancer stem cells have many jeans, transcription factors, and signaling pathways in common. Both have been clinically correlated with patient outcomes and disease-free survival. There's currently no consensus on mechanistic connection between the two phenomena. The current data on critical signaling pathways as well as the effect of the tumor stroma and cytotoxic therapy is examined. The current body of research points to the conclusion that EMT may be responsible for the cancer stem cell-enriched populations in solid tumors.en_US
dc.language.isoen_USen_US
dc.publisherBoston Universityen_US
dc.titleAn examination of the relationship between epithelial to mesenchymal transition and cancer stem cells in solid tumorsen_US
dc.typeThesis/Dissertationen_US
etd.degree.nameMaster of Artsen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


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