Boston University Libraries OpenBU
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    •   OpenBU
    • Theses & Dissertations
    • Boston University Theses & Dissertations
    • View Item
    •   OpenBU
    • Theses & Dissertations
    • Boston University Theses & Dissertations
    • View Item

    Comparison of skeletal morphology of Brd2 heterozygous mice against wild type C57/B6J mice

    Thumbnail
    Date Issued
    2012
    Author(s)
    Burns, Robert
    Share to FacebookShare to TwitterShare by Email
    Export Citation
    Download to BibTex
    Download to EndNote/RefMan (RIS)
    Metadata
    Show full item record
    Embargoed until:
    Indefinite
    Permanent Link
    https://hdl.handle.net/2144/12302
    Abstract
    Objectives: The purpose of the study was to characterize age related bone lose in male and female mice lacking one functional copy of the Brd2 gene. These mice will develop age related obesity but will not develop Type II diabetes that is normally associated with obesity. Thus age and sex related changes in the skeletal morphology and structure can be assessed in response to obesity but not be confounded by the development of insulin resistance that is known to effect bone mass. Methods: Wild type and Brd2 heterozygote male and female mice were allowed to age under normal conditions in which they were fed ad libitum. Skeletal morphology and structure was assessed via µCT of the proximal metaphysis for the trabecular architecture and for the mid-diaphyseal region to assess cortical. Results: Genotype was found to play a significant role in affecting trabecular architecture in females for BV/TV, connective density, trabecular number, thickness and separation and in males for degree of anisotropy. An age-bygenotype was found to play a significant role in affecting cortical architecture in males for cortical area, total area, cortical area/total area, and medullary area. Conclusion: Brd2 heterozygote mice have significantly altered structural parameters from that of their wild type counterparts. These differences in how genotype affected the sexes suggests that the Brd2 protein is affected by sex dependent mechanism related to general metabolism and adiposity independent of insulin function.
    Description
    Thesis (M.A.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.
    Collections
    • Boston University Theses & Dissertations [6746]


    Boston University
    Contact Us | Send Feedback | Help
     

     

    Browse

    All of OpenBUCommunities & CollectionsIssue DateAuthorsTitlesSubjectsThis CollectionIssue DateAuthorsTitlesSubjects

    Deposit Materials

    LoginNon-BU Registration

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Boston University
    Contact Us | Send Feedback | Help