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dc.contributor.authorBurns, Roberten_US
dc.date.accessioned2015-08-04T18:18:50Z
dc.date.available2015-08-04T18:18:50Z
dc.date.issued2012
dc.date.submitted2012
dc.identifier.other(ALMA)contemp
dc.identifier.urihttps://hdl.handle.net/2144/12302
dc.descriptionThesis (M.A.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.en_US
dc.description.abstractObjectives: The purpose of the study was to characterize age related bone lose in male and female mice lacking one functional copy of the Brd2 gene. These mice will develop age related obesity but will not develop Type II diabetes that is normally associated with obesity. Thus age and sex related changes in the skeletal morphology and structure can be assessed in response to obesity but not be confounded by the development of insulin resistance that is known to effect bone mass. Methods: Wild type and Brd2 heterozygote male and female mice were allowed to age under normal conditions in which they were fed ad libitum. Skeletal morphology and structure was assessed via µCT of the proximal metaphysis for the trabecular architecture and for the mid-diaphyseal region to assess cortical. Results: Genotype was found to play a significant role in affecting trabecular architecture in females for BV/TV, connective density, trabecular number, thickness and separation and in males for degree of anisotropy. An age-bygenotype was found to play a significant role in affecting cortical architecture in males for cortical area, total area, cortical area/total area, and medullary area. Conclusion: Brd2 heterozygote mice have significantly altered structural parameters from that of their wild type counterparts. These differences in how genotype affected the sexes suggests that the Brd2 protein is affected by sex dependent mechanism related to general metabolism and adiposity independent of insulin function.en_US
dc.language.isoen_US
dc.publisherBoston Universityen_US
dc.titleComparison of skeletal morphology of Brd2 heterozygous mice against wild type C57/B6J miceen_US
dc.typeThesis/Dissertationen_US
etd.degree.nameMaster of Artsen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


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