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dc.contributor.authorGil, Julie Zeskinden_US
dc.date.accessioned2015-08-04T20:22:03Z
dc.date.available2015-08-04T20:22:03Z
dc.date.issued2012en_US
dc.date.submitted2012en_US
dc.identifier.other(ALMA)contempen_US
dc.identifier.urihttps://hdl.handle.net/2144/12395
dc.descriptionThesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.en_US
dc.description.abstractChronic Obstructive Pulmonary Disease (COPD) is a disease of reduced lung function. It is the fourth leading cause of death in the US. In the US it is primarily caused by smoking, yet only 10-20% of smokers will develop COPD. The exact molecular and genetic mechanisms contributing to the disease are unknown. Current therapies reduce symptoms but cannot halt the lung function decline. COPD is comprised of two subphenotypes - emphysema (alveolar destruction) and small airway disease (airway-wall thickening). The relative combination of airway disease and emphysema is heterogeneous between patients. The degree of disease is heterogeneous within each patient. This study takes two unique approaches to gain insights into the molecular processes that contribute to airway thickening and alveolar destruction. First, it utilizes the regional heterogeneity in each patient as a surrogate for disease progression. Second, it examines the airway disease and emphysematous components separately. [TRUNCATED]en_US
dc.language.isoen_USen_US
dc.publisherBoston Universityen_US
dc.titleGene expression alterations associated with progression of emphysema and small airway disease in smokers with COPDen_US
dc.typeThesis/Dissertationen_US
etd.degree.nameDoctor of Philosophyen_US
etd.degree.leveldoctoralen_US
etd.degree.disciplineBioinformaticsen_US
etd.degree.grantorBoston Universityen_US


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