A mechanism based approach to evaluating adverse drug reactions in a medico-legal setting
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The following thesis is an evaluation of the various mechanistic underpinnings of adverse drug reactions, including prescription drug-drug, drug-food, and dru gsupplement interactions, as well as "type B" adverse drug reactions, and adverse drug reactions arising from medication errors. The mechanisms associated with each of these categories are presented and supported through published studies and case reports. Furthermore, the aforementioned adverse drug reactions are associated with risk factors and severe, or fatal, adverse drug reactions are assessed within a medico-legal context for their relevance and prevalence. It was found that there is an insufficient amount of published data, especially within the United States, to determine the overall degree to which fatal adverse drug reactions may influence post-mortem analysis and outcomes of medico-legal investigation.
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