The good, the bad and the ugly: apolipoprotein E and Alzheimer's disease
Kitts, Connor Lindsay
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Alzheimer disease has fully entered the public consciousness. The prevalence of the disease means that nearly everyone in the West has had some contact or experience to consider when a discussion comes up. From the outside, it is difficult to understand what life must be like for people with Alzheimer disease. Understanding the slow loss of acuity and independence, or the shock of an early, aggressive Alzheimer diagnosis is almost impossible. Unlike so many other diseases, Alzheimer disease and other dementias are a front seat ride toward forgotten memories, thoughts just out of reach, and the endless frustration that comes with knowing that it will likely only get worse. Like so many other biological systems, each revelation in Alzheimer research is mostly an awakening; a realization that the mechanisms behind the curtain are possibly more complicated than anticipated. However, a series of discoveries in recent years have raised spirits. Researchers have not completed the puzzle, but they have developed a strong comer. The overlap of Alzheimer disease and other body system, to the optimist, are access points. In this discussion, the strange and exciting ways that Alzheimer disease and lipid regulation interact will be considered. Specifically, the apolipoprotein E and its dual nature in Alzheimer pathogenesis will be reviewed in detail. Toward the end of the discussion, time will be spent on some very recent publications that may lead to viable therapeutics for people with Alzheimer disease.
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