Cellular casistas b-lineage lymphoma mediated migration of primary fibroblasts in response to 3',3',5'-triiodothyronine hormone to increase would healing in diabetic mice
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Background: Cutaneous wounds in the diabetics display delayed healing and inflammatory response resulting in a chronic condition that can be life threatening. This chronic condition has been linked to increase in reactive Oxygen Species (Hossam Ebaid, 2011). In healthy individuals wound healing is a process involving cytokine release, angiogenesis, cell migration and proliferation, break down of the extracellular matrix, regeneration of extracellular martix and re-epithelialization. This study was designed to investigate one of the processes involved in wound healing that is fibroblast migration in hopes of finding ways to decrease the time it takes to heal the wound, decrease chances of a chronic condition as well as decrease chances of infections that can be life threatning. The particular aim of this study was to study the effects of thyroid hormone (T3) on migration offibrob1ast. Methods: The methods used in this project include Western Blotting, cell passing, cell dosage, cell lysis and photo-imaging. Results: In response to thyroid hormone (T3), the levels of cellular casitas b-lineage lymphoma were down regulated in vitro. Conclusion: Our resutls showed that c-cbl, a proteins that plays a critical role in fibroblast migration, was down regulated by thyroid hormone.
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