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dc.contributor.authorMedeiros, Kyle Andrewen_US
dc.date.accessioned2015-08-05T00:54:28Z
dc.date.available2015-08-05T00:54:28Z
dc.date.issued2012en_US
dc.date.submitted2012en_US
dc.identifier.other(ALMA)contempen_US
dc.identifier.urihttps://hdl.handle.net/2144/12516
dc.descriptionThesis (M.A.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.en_US
dc.description.abstractPolymorphonuclear leukocytes (neutrophils) play a major role in fighting off invading bacteria. They are the first of the inflammatory cells to migrate to sites of inflammation through a process known as chemotaxis. Neutrophils eliminate invading organisms is by phagocytosis. Each phagocytic event results in the accumulation of reactive oxygen species such as the superoxide. Under hypoxic conditions associated with inflammation at local tissues, a set of transcription factors known as hypoxia-inducible factors are activated. This family of transcription factors consists primarily of two members, hypoxia inducible factor-1 (HIF-1) and hypoxia inducible factor-2 (HIF-2). HIF-1 is a heterodimer composed of alpha and beta subsets. In this study, we examined the expression of HIF-1α, HIF-1β and HIF-2 in neutrophils under hypoxic conditions at different time intervals. Expression of HIF -1α significantly increased under hypoxic conditions as compared to the normoxia. The results provide evidence suggesting that HIF-1α is the primary factor in mediating oxygen homeostasis under hypoxic conditions by regulating superoxide generation in neutrophils.en_US
dc.language.isoen_USen_US
dc.publisherBoston Universityen_US
dc.titleHypoxia and the activity of neutrophilsen_US
dc.typeThesis/Dissertationen_US
etd.degree.nameMaster of Artsen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


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