Physical Therapy & Athletic Training
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URI: http://hdl.handle.net/2144/1279
The Department of Physical Therapy and Athletic Training at BU Sargent College is dedicated to promoting the health of all people and the rehabilitation of people with injury or disease. Our programs combine a strong foundation in basic sciences with the applied sciences in movement disorders and an emphasis on clinical experience, Our distinctive interdisciplinary, evidence-based approach combines challenging coursework, real-world research opportunities, custom-tailored clinical placements, and the opportunity to collaborate with faculty who are leaders in their fields.
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Factors affecting antimicrobial activity of MUC7 12-mer, a human salivary mucin-derived peptide
(2007-11-11)BACKGROUND: MUC7 12-mer (RKSYKCLHKRCR), a cationic antimicrobial peptide derived from the human low-molecular-weight salivary mucin MUC7, possesses potent antimicrobial activity in vitro. In order to evaluate the potential ... -
Gluten degrading enzymes for treatment of celiac disease
(2020-07-15)Celiac disease (CeD) affects about 1% of most world populations. It presents a wide spectrum of clinical manifestations, ranging from minor symptoms to mild or severe malabsorption, and it may be associated with a wide ... -
Short-term ONX-0914 administration: performance and muscle phenotype in Mdx mice
(2020-07-19)Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disease. Although the lack of dystrophin protein is the primary defect responsible for the development of DMD, secondary disease complications such as persistent ... -
Commensal bacterium Rothia aeria degrades and detoxifies gluten via a highly effective subtilisin enzyme
(2020-12-02)Celiac disease is characterized by a chronic immune-mediated inflammation of the small intestine, triggered by gluten contained in wheat, barley, and rye. Rothia aeria, a gram-positive natural colonizer of the oral cavity ... -
Identification of pseudolysin (lasB) as an aciduric gluten-degrading enzyme with high therapeutic potential for celiac disease
(Wolters Kluwer Health, Inc., 2015-06)OBJECTIVES Immunogenic gluten proteins implicated in celiac disease (CD) largely resist degradation by human digestive enzymes. Here we pursued the isolation of gluten-degrading organisms from human feces, aiming at ... -
Pharmaceutically modified subtilisins withstand acidic conditions and effectively degrade gluten in vivo
(Nature Publishing Group, 2019-05-16)Detoxification of gluten immunogenic epitopes is a promising strategy for the treatment of celiac disease. Our previous studies have shown that these epitopes can be degraded in vitro by subtilisin enzymes derived from ... -
Home-based physical therapy with an interactive computer vision system
(2019-10-28)In this paper, we present ExerciseCheck. ExerciseCheck is an interactive computer vision system that is sufficiently modular to work with different sources of human pose estimates, i.e., estimates from deep or traditional ... -
Are the 10 meter and 6 minute walk tests redundant in patients with spinal cord injury?
(Public Library of Science, 2014-05-01) -
Novel individualized power training protocol preserves physical function in adult and older mice
(Springer Nature Switzerland AG, 2019-04)Sarcopenia, the age-related loss of muscle mass and strength, contributes to frailty, functional decline, and reduced quality of life in older adults. Exercise is a recognized therapy for sarcopenia and muscle dysfunction, ... -
Downhill exercise alters immunoproteasome content in mouse skeletal muscle
(Springer, 2018-07-01)Content of the immunoproteasome, the inducible form of the standard proteasome, increases in atrophic muscle suggesting it may be associated with skeletal muscle remodeling. However, it remains unknown if the immunoproteasome ...
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