Physical Therapy & Athletic Training
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URI: http://hdl.handle.net/2144/1279
The Department of Physical Therapy and Athletic Training at BU Sargent College is dedicated to promoting the health of all people and the rehabilitation of people with injury or disease. Our programs combine a strong foundation in basic sciences with the applied sciences in movement disorders and an emphasis on clinical experience, Our distinctive interdisciplinary, evidence-based approach combines challenging coursework, real-world research opportunities, custom-tailored clinical placements, and the opportunity to collaborate with faculty who are leaders in their fields.
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These legs were made for propulsion: advancing the diagnosis and treatment of post-stroke propulsion deficits
(2020-10-21)Advances in medical diagnosis and treatment have facilitated the emergence of precision medicine. In contrast, locomotor rehabilitation for individuals with acquired neuromotor injuries remains limited by the dearth of (i) ... -
Indirect measurement of anterior-posterior ground reaction forces using a minimal set of wearable inertial sensors: from healthy to hemiparetic walking
(2020-06-29)BACKGROUND: The anterior-posterior ground reaction force (AP-GRF) and propulsion and braking point metrics derived from the AP-GRF time series are indicators of locomotor function across healthy and neurological diagnostic ... -
The ReWalk ReStore™ soft robotic exosuit: a multi-site clinical trial of the safety, reliability, and feasibility of exosuit-augmented post-stroke gait rehabilitation
(2020-06-18)BACKGROUND: Atypical walking in the months and years after stroke constrain community reintegration and reduce mobility, health, and quality of life. The ReWalk ReStore™ is a soft robotic exosuit designed to assist the ... -
Design of the WHIP-PD study: a phase II, twelve-month, dual-site, randomized controlled trial evaluating the effects of a cognitive-behavioral approach for promoting enhanced walking activity using mobile health technology in people with Parkinson-disease
(2020-04-20)BACKGROUND: Parkinson disease (PD) is a debilitating and chronic neurodegenerative disease resulting in ambulation difficulties. Natural walking activity often declines early in disease progression despite the relative ... -
Factors affecting antimicrobial activity of MUC7 12-mer, a human salivary mucin-derived peptide
(2007-11-11)BACKGROUND: MUC7 12-mer (RKSYKCLHKRCR), a cationic antimicrobial peptide derived from the human low-molecular-weight salivary mucin MUC7, possesses potent antimicrobial activity in vitro. In order to evaluate the potential ... -
Gluten degrading enzymes for treatment of celiac disease
(2020-07-15)Celiac disease (CeD) affects about 1% of most world populations. It presents a wide spectrum of clinical manifestations, ranging from minor symptoms to mild or severe malabsorption, and it may be associated with a wide ... -
Short-term ONX-0914 administration: performance and muscle phenotype in Mdx mice
(2020-07-19)Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disease. Although the lack of dystrophin protein is the primary defect responsible for the development of DMD, secondary disease complications such as persistent ... -
Commensal bacterium Rothia aeria degrades and detoxifies gluten via a highly effective subtilisin enzyme
(2020-12-02)Celiac disease is characterized by a chronic immune-mediated inflammation of the small intestine, triggered by gluten contained in wheat, barley, and rye. Rothia aeria, a gram-positive natural colonizer of the oral cavity ... -
Identification of pseudolysin (lasB) as an aciduric gluten-degrading enzyme with high therapeutic potential for celiac disease
(Wolters Kluwer Health, Inc., 2015-06)OBJECTIVES Immunogenic gluten proteins implicated in celiac disease (CD) largely resist degradation by human digestive enzymes. Here we pursued the isolation of gluten-degrading organisms from human feces, aiming at ... -
Pharmaceutically modified subtilisins withstand acidic conditions and effectively degrade gluten in vivo
(Nature Publishing Group, 2019-05-16)Detoxification of gluten immunogenic epitopes is a promising strategy for the treatment of celiac disease. Our previous studies have shown that these epitopes can be degraded in vitro by subtilisin enzymes derived from ...
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