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dc.contributor.authorReinhardt, Benjaminen_US
dc.date.accessioned2015-09-04T12:52:53Z
dc.date.available2015-09-04T12:52:53Z
dc.date.issued2015-08
dc.identifier.urihttps://hdl.handle.net/2144/12970
dc.descriptionPoster presentation at REU Summer's End Research Symposium, 2015, by REU participant Ben Reinhardt, St. John Fisher College - Aaron Beeler group, Alexis Young lab mentor.en_US
dc.description.abstractCyathane natural products were proven biologically relevant molecules as they stimulate the expression of NGF. As such some cyathanes are potential therapeutic agents for Alzheimer’s disease. A preliminary pharmacophore model was produced which consists of a simplified seven-six bicyclic molecular scaffold. A synthetic route could utilize the Buchner reaction, but until this time only unsubstituted, carbonyl stabilized diazo compounds have been used due to the explosive nature of other diazo species. Such a bicyclic compound would require further modification to remove the carbonyl functional group. Flow chemistry was utilized to overcome these restrictions with the Buchner Reaction. 1-(4-diazopentyl)-2-methoxybenzene was used as the model substrate, and numerous electronic and substitution analogs were synthesized to further expand the scope of the Buchner Reaction in flow. Optimizing the flow reaction to use unprotected hydrazine to form a free hydrazone intermediate in situ was also explored. The (5-(2-methoxyphenyl)pentan-2-yl) hydrazone was successfully formed, while further results are yet pending.en_US
dc.language.isoen_US
dc.rightsCC0 1.0 Universalen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/
dc.title2015 REU Poster: Cyathane Inspired Scaffold Synthesis in Flowen_US
dc.typePresentationen_US


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