2014 REU Poster: Synthesis of Novel Beta-Amyloid Oligomer Inhibitors for the Treatment of Alzheimer's Disease
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Alzheimer's disease is a condition which affects over five million Americans, making it the sixth leading cause of death in the United States. This, combined with the fact that Alzheimer’s currently had no known cure, makes it a particularly expensive drain on the medical industry. In the 2013 fiscal year alone, caregivers provided a total of 17.7 billion unpaid care hours, which amounts to over $220 billion. A certain ligand (DS-26) , which has been previously proven to be effective against Alzheimer’s in in silico studies was synthesized and tested via Surface Plasmon Resonance (SPR). In addition, variations of this ligand ( DS-207 through DS-307) were synthesized and tested via SPR as well.
Poster presentation at REU Summer's End Research Symposium, 2014, by REU participant Gerardo Colon, Universidad Metropolitana, Puerto Rico - Aaron Beeler group, Alexis Young lab mentor.