Brain changes in presymptomatic early-onset Alzheimer's disease
Quiroz-Gaviria, Yakeel T.
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What are the earliest brain changes associated with genetic predisposition to Alzheimer's disease (AD)? This thesis used structural and functional magnetic resonance imaging (MRI) and event-related potentials (ERP) to examine brain function in cognitively normal individuals who carry an early-onset AD-causing presenilin-1 (PSEN1) E280A genetic mutation. The research was carried out in four experiments: 1) fMRI activity during associative learning, 2) fMRI activity during successful novel picture encoding, 3) MRI cortical thickness using a set of a priori regions of interest, and 4) ERP neural correlates ofrecognition memory. Thirty-nine 25-44 year-old presymptomatic PSEN1 mutation carriers (MC) and non-carriers (NC) were studied. Nineteen PSEN1 MC and 20 NC participated in studies 1, 2 and 3 in single scanning sessions. Twenty-one ofthese individuals (10 MC and 11 NC) also participated in experiment 4. [TRUNCATED]
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