Effects of p21 on HIV transcription
Chapman, Blake Edward
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HIV represents a global health problem. The phenomenon of HIV latency presents challenges in treating and curing HIV infection. Understanding the mechanisms behind HIV latency may provide the route to cure HIV. In a subset of elite controllers, elevated levels of p21 provide resistance to HIV replication by inhibiting transcription. I attempted to understand the mechanisms by overexpressing p21 in HEK 293T cells.