Provider practices in the management of primary hypothyroidism due to autoimmune thyroiditis
Pardamean, Carissa Ikka
MetadataShow full item record
Thyroid hormone is a master regulator of growth and development in all vertebrates. Thus, disruption of its synthesis and activity can lead to profound consequences. Past decade studies on thyroid function tests have established an efficient guideline for monitoring thyroid diseases, yet a significant proportion of healthcare providers do not defer to it in their practice. The aim of this study is to assess provider practices in the diagnosis and treatment of primary hypothyroidism due to autoimmunity at Boston Children's Hospital (CHB) for a primarily pediatric patient population. Commonly known as Hashimoto's thyroiditis (HT), this is the most common thyroid disease in the world as well as the most common manifestation of human autoimmune endocrine disease. Through CHB's bioinformatics institute, a rich data set was collected to assess the manner in which healthcare providers utilized relevant thyroid function tests (TFTs). This work assessed and confirmed the superior sensitivity of thyroid peroxidase autoantibodies (TPO) relative to thyroglobulin antibodies (TgAb) for diagnosing HT in children. We also verified proper utilization of thyroid stimulating hormone tests to monitor HT but concluded that there is a low utilization efficiency with regards to measurements of thyroid hormones (thyroxine and triiodothyronine). Based upon the observation of unnecessary monetary loss caused by improper TFTs utilization, it can be concluded that reflex testing at CHB may improve provider practices' efficiency for HT monitoring.
Showing items related by title, author, creator and subject.
Thyroid horomone and wound healing: HIF-1 alpha A potential thyroid responsive protein. MMP-2, MMP-9, and TIMP-2 thyroid independent proteins. Stratton, Michael (Boston University, 2012)Wound healing is a dynamic and tightly regulated orchestration of cells and proteins. The process is generally subdivided into three stages that overlap in space and time; they are hemostasis, inflammation, and proliferation. ...
The effect of thyroid hormone-dependent dermal fibroblast proliferation: an investigation of connective tissue growth factor and proliferative cell nuclear antigen Moroney, James B. (Boston University, 2013)Thyroid hormone has significant impact on skin homeostasis and cutaneous wound healing. Previous research has demonstrated both in vitro proliferation of keratinocytes and fibroblasts and in vivo stimulation of epidermal ...
The interrelation between thyroid, bypophysis and adrenals under conditions of stress, with especial reference to pituitary cytology McNary, William Francis (Boston University, 1954)The purpose of this investigation was to study the interrelation, in the rat, between the adrenal gland and the hypophysis, and between the thyroid gland and the hypophysis with respect to changes in the cytological structure ...