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dc.contributor.authorLindquist, Mirabelleen_US
dc.date.accessioned2016-02-25T15:24:56Z
dc.date.available2016-02-25T15:24:56Z
dc.date.issued2016
dc.identifier.urihttps://hdl.handle.net/2144/14596
dc.description.abstractHuman calf muscle injuries are relatively common among individuals from various backgrounds. Miniscule tears in the muscles of the calf such as the medial gastrocnemius, lateral gastrocnemius, and soleus, may be difficult to identify using traditional imaging modalities. Diffusion kurtosis imaging (DKI), is one type of diffusion imaging that has presented with some strengths over diffusion tensor imaging (DTI) and diffusion weighted imaging (DWI). Though DTI studies in the human calf have been published, no DKI studies in the human calf exist to our knowledge. The objective of this study is to determine whether or not DKI is applicable in identifying quantitative changes between states of dorsiflexion and relaxation in the human calf. One female participant underwent DKI. Data from the scanning was quantitatively analyzed via the use of FSLView and the NODDI MATLAB toolbox. A change in mean voxel intensity in the calf and mean orientation dispersion index was identified in each of the five slices analyzed, in each muscle group (medial gastrocnemius, lateral gastrocnemius, and soleus). Most of the changes, whether an increase or decrease in mean value—between the states of dorsiflexion and relaxation—were statistically significant. We conclude that DKI may have a future in identifying physical/quantitative changes in calf muscles between the tense/relaxed states. Further studies using DKI on the human calf should be conducted in the future and address the limitations of the current study. Further investigation could possibly benefit individuals with miniscule calf muscle injuries.en_US
dc.language.isoen_US
dc.subjectMedical imagingen_US
dc.titleDiffusion kurtosis imaging (DKI) in the human calf musclesen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2016-02-17T20:20:01Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineBioimagingen_US
etd.degree.grantorBoston Universityen_US


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