Show simple item record

dc.contributor.authorHarrison, Nicholas Roberten_US
dc.date.accessioned2016-02-26T14:36:51Z
dc.date.available2016-06-30T06:00:59Z
dc.date.issued2016
dc.identifier.urihttps://hdl.handle.net/2144/14620
dc.description.abstractImproved therapeutic strategies for patients with leukemia remain in great demand and beckon better understanding of the mechanisms underlying leukemic treatment resistance and relapse. Accordingly, discoveries in leukemic pathophysiology have been achieved in various animal models. Danio rerio—commonly known as the zebrafish—is a vertebrate organism well suited for the investigation of human leukemia. Zebrafish have a conserved hematopoietic program and unique experimental strengths. Recent technological advances in zebrafish research including efficient transgenesis, precise genome editing, and straightforward transplantation techniques have led to the generation of numerous zebrafish leukemia models. Additionally, improved imaging techniques, combined with the transparency of zebrafish, have revealed exquisite details of leukemic initiation, progression, and regression. Finally, advances in high-throughput drug screening in zebrafish are likely to hasten the discovery of novel anti-leukemic agents. Zebrafish provide a reliable experimental system for leukemic disease research and one in which investigators have accumulated knowledge concerning the genetic underpinnings of leukemic transformation and treatment resistance. Without doubt, zebrafish are rapidly expanding our understanding of disease mechanism and are helping to shape therapeutic strategy for improved patient outcomes.en_US
dc.language.isoen_US
dc.subjectPharmacologyen_US
dc.subjectDanio rerioen_US
dc.subjectLeukemiaen_US
dc.subjectTransplantationen_US
dc.subjectXenograften_US
dc.subjectZebrafishen_US
dc.titleZebrafish models of human leukemia: technological advances and mechanistic insightsen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2016-02-17T20:20:29Z
etd.degree.nameM.A.en_US
etd.degree.levelmastersen_US
etd.degree.disciplinePharmacology & Experimental Therapeuticsen_US
etd.degree.grantorBoston Universityen_US


This item appears in the following Collection(s)

Show simple item record