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dc.contributor.authorBerman, Herbert Joshua
dc.date.accessioned2016-03-03T16:38:15Z
dc.date.available2016-03-03T16:38:15Z
dc.date.issued1953
dc.date.submitted1953
dc.identifier.otherb14649068
dc.identifier.urihttps://hdl.handle.net/2144/14944
dc.descriptionThesis (Ph.D.)--Boston University
dc.description.abstractThe hamster, because of its unique cheek pouch permitting direct microscopic observation of the circulation, is peculiarly suited for the study of peripheral vascular changes in normal and abnormal conditions. The initial problem in hypertensive work on the hamster was to find and then develop an indirect and noninjurious method of determining the blood pressure. Five indirect methods of measuring the blood pressure of the hamster were considered and the method of applying a cuff across the proximal portion of the cheek pouch was selected for development. [TRUNCATED] It was concluded that the blood pressure of the hamster is significantly elevated by encapsulation of the kidney with latex or silk. The elevation of blood pressure brought about by collodion encapsulation was not considered significant. The elevation of blood pressure in apparently healthy hamsters with encapsulated kidneys was not accompanied by increased susceptibility to vascular fragility as determined by positive and negative pressure tests, nor were indications of concomitant pathological changes in the blood vessel walls, such as arteriolitis or aneurysms, observed. The administration of an egg-yolk diet, of DOCA alone, or of a combination of DOCA and sodium chloride did not result in an elevation of blood pressure in the hamster. DOCA and sodium chloride administered together proved lethal.
dc.language.isoen_US
dc.publisherBoston University
dc.rightsBased on investigation of the BU Libraries' staff, this work is free of known copyright restrictions.
dc.titleObservations on the blood pressure of the golden hamster (mesocricetus auratus).en_US
dc.typeThesis/Dissertation
etd.degree.nameDoctor of Philosophy
etd.degree.leveldoctoral
etd.degree.disciplineBiology
etd.degree.grantorBoston University


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