Boston University Libraries OpenBU
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    •   OpenBU
    • Theses & Dissertations
    • Boston University Theses & Dissertations
    • View Item
    •   OpenBU
    • Theses & Dissertations
    • Boston University Theses & Dissertations
    • View Item

    Antecedent medication use and volume of ischemic stroke: a clinical and neuroimaging evaluation

    Thumbnail
    Date Issued
    2014
    Author(s)
    Shideler, Kelsey Idina
    Share to FacebookShare to TwitterShare by Email
    Export Citation
    Download to BibTex
    Download to EndNote/RefMan (RIS)
    Metadata
    Show full item record
    Embargoed until:
    Indefinite
    Permanent Link
    https://hdl.handle.net/2144/15088
    Abstract
    Stroke is the second most common cause of mortality in the world, and is the leading cause of disability in the United States. It is unclear whether cerebral infarct size is influenced by antecedent medication use in humans. The goal of this study was to investigate the possible influences of prior medication use on cerebral infarct volume in humans. We retrospectively analyzed a prospectively enrolled cohort of patients with acute ischemic stroke. Cerebral infarct volume was measured using a previously published method with high inter-rater reliability, based on a semi-automated image analysis program. We studied the association between these volumes with qualitative and quantitative data regarding medication use prior to onset of stroke symptoms. Diffusion Weighted Imaging volume was measured in 642 patients with acute ischemic stroke (mean age 64.9 years, median volume 2.5 cm3). In univariate analysis, medication use showed no effect on infarct volume, with only a slight, non-significant reduction in volume seen in patients with a history of aspirin use (OR=0.63; 95% Confidence Interval (CI) = 0.47-0.84). Based on these findings, we concluded that in patients with acute ischemic stroke, previous medication use does not appear to correlate with infarct volume.
    Collections
    • Boston University Theses & Dissertations [6758]


    Boston University
    Contact Us | Send Feedback | Help
     

     

    Browse

    All of OpenBUCommunities & CollectionsIssue DateAuthorsTitlesSubjectsThis CollectionIssue DateAuthorsTitlesSubjects

    Deposit Materials

    LoginNon-BU Registration

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Boston University
    Contact Us | Send Feedback | Help