Boston University Libraries OpenBU
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    •   OpenBU
    • Theses & Dissertations
    • Boston University Theses & Dissertations
    • View Item
    •   OpenBU
    • Theses & Dissertations
    • Boston University Theses & Dissertations
    • View Item

    Noninvasive and targeted interruption of the blood brain barrier for drug delivery using focused ultrasound in the treatment of CNS disorders

    Thumbnail
    Date Issued
    2014
    Author(s)
    Gao, Zimeng
    Share to FacebookShare to TwitterShare by Email
    Export Citation
    Download to BibTex
    Download to EndNote/RefMan (RIS)
    Metadata
    Show full item record
    Permanent Link
    https://hdl.handle.net/2144/15316
    Abstract
    Despite the prevalence of CNS disorders, treatment options for CNS disorders fall woefully behind treatment options for other systemic disorders. This is due to the presence of the blood brain barrier (BBB) acting as an obstacle, preventing foreign substances from entering the brain. A newly developed and innovative biomedical procedure attempts to bypass the BBB in the delivery of therapeutics by using focused ultrasound (FUS) to disrupt and temporarily open the BBB. The use of FUS-facilitated BBB opening is able to target specific tissue for noninvasive, localized BBB penetration. As the technique is experimental and in it's nascent stage of development, there are only a few studies that investigate its abilities in delivering treatments directly to the brain. The studies involve delivery of large, hydrophilic molecules that traditionally would not be able to bypass the BBB and enter the brain, and analysis of CNS concentrations of the molecules after FUS treatment, as well as the therapeutic successes. Results of FUS the studies are promising and the results demonstrate that the procedure is able to significantly increase drug concentrations in the brain, increase survival rates in animal models, decrease tumor growth, and decrease tumor margins and volume. The potential and power of FUS should be further explored as the future of CNS disorder treatments.
    Collections
    • Boston University Theses & Dissertations [6950]


    Boston University
    Contact Us | Send Feedback | Help
     

     

    Browse

    All of OpenBUCommunities & CollectionsIssue DateAuthorsTitlesSubjectsThis CollectionIssue DateAuthorsTitlesSubjects

    Deposit Materials

    LoginNon-BU Registration

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Boston University
    Contact Us | Send Feedback | Help