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dc.contributor.authorKavensky, Elisseen_US
dc.date.accessioned2016-03-28T14:32:12Z
dc.date.available2016-03-28T14:32:12Z
dc.date.issued2014
dc.identifier.urihttps://hdl.handle.net/2144/15324
dc.description.abstractConnexin 43 (Cx43) is a gap junction protein that enables direct cell-to-cell communication in many tissues of the body and stressful environments such as injury and hypoxia affect its expression. In addition to affecting Cx43 expression, hypoxia also retards wound-healing rates. Using rat corneal organ cultures, this thesis aims to define hypoxia's role in the expression and localization of Cx43 in wounded corneas. Tissue samples were stained immunohistochemically at three different time points after injury, 2.5 hours, 5 hours, and 18 hours. It was determined that under hypoxic conditions, Cx43 is more highly expressed than under normoxic conditions after injury. While Cx43 expression follows the same spatial pattern throughout the healing process in the cornea under both normoxic and hypoxic conditions, the pattern is delayed under hypoxic conditions. These results provide a possible reason why wound closure is delayed in low oxygen environments.en_US
dc.language.isoen_US
dc.subjectBiochemistryen_US
dc.subjectConnexin 43en_US
dc.subjectCorneaen_US
dc.subjectHypoxiaen_US
dc.titleRole of hypoxia in expression and localization of Connexin 43en_US
dc.typeThesis/Dissertationen_US
dc.date.updated2016-03-12T07:11:25Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


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