A retrospective cohort study to determine the risk difference in survival in locoregional recurrence and distant disease of breast cancer in premenopausal women treated with breast-conserving therapy or mastectomy at Massachusetts General Hospital
Najjar, Anas Latif
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PURPOSE: The purpose of this study was to determine if there is a risk difference in survival in the first event of locoregional recurrence and distant disease in women who underwent breast-conserving therapy (BCT) compared with women who underwent mastectomy. Premenopausal women with early-stage breast cancer and positive lymph node/s make up this group. METHODS: Retrospective cohort study was conducted to answer this study question by a chart review. RESULTS: The results of the study demonstrated that women with breast cancer who underwent mastectomy had higher risk of distant disease compared with breast-conserving therapy. Also women aged under 35 had an independent association with distant disease. In addition, the type of surgery did not have a significant result association with locoregional recurrence. CONCLUSIONS: These results support the fact that the breast-conserving therapy group had a low rate of distant disease compared with the mastectomy group. Also they endorse the necessity to conduct further descriptive studies to address the association between type of surgery and locoregional recurrence.