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dc.contributor.authorZhu, Hao
dc.date.accessioned2016-04-07T17:41:18Z
dc.date.available2016-04-07T17:41:18Z
dc.date.issued2015
dc.identifier.urihttps://hdl.handle.net/2144/15619
dc.description.abstractPoor adherence is an issue in clinical trials with a striking magnitude and negative impact. Recent studies indicate that two widely used clinical screening tools, Short Form (SF-36) Health Survey and Center for Epidemiologic Studies Depression Scale (CES-D) can be used as risk stratifiers to identify participants who require extra interaction to stay adherent in specific population. There is, however, little evidence to support the implication of these tools in elderly individuals with mobility limitations. These individuals may be particularly vulnerable to the risks of poor adherence in the context of a demanding interventional scheme. This study fulfills this gap by analyzing the quality of life and adherence data from the VIVE2 study, which is a double-blinded randomized explanatory clinical trial assessing the benefits of nutritional supplements and daily exercises to elderly patients with mobility limitation. The preliminary results showed that in clinical studies targeting elderly population with mobility limitations, the summary scores of SF-36 trended to have weak and nonsignificant association with a decreased risk of poor adherence to both exercise completion and product consumption while CES-D has no association.en_US
dc.language.isoen_USen_US
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMedicineen_US
dc.subjectAdherenceen_US
dc.subjectCES-Den_US
dc.subjectComplianceen_US
dc.subjectElderlyen_US
dc.subjectMobilityen_US
dc.subjectSF-36en_US
dc.titleQuality of life and depressive symptoms as predictors of participant adherence in a randomized trial conducted among older adults at risk of mobility disabilityen_US
dc.typeThesis/Dissertation
dc.date.updated2016-03-12T07:13:40Z
etd.degree.nameM.A.en_US
etd.degree.levelmastersen_US
etd.degree.disciplineClinical Investigationen_US
etd.degree.grantorBoston Universityen_US


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International