Show simple item record

dc.contributor.authorLee, Rebecca Arwynen_US
dc.date.accessioned2016-04-22T14:37:43Z
dc.date.issued2015
dc.identifier.urihttps://hdl.handle.net/2144/16050
dc.description.abstractAs we learn more about immune cell subpopulations, we find an increasingly complex system of cells with diverse functions. L2pB1 cells are a PD-L2 positive B1a B lymphocyte subpopulation that has unusual properties and characteristics that are not fully understood by many. By creating and implementing a transgenic mouse model that allows for targeted depletion of this specific group of cells, we can further elucidate their physiological functions and roles in both healthy and diseased states. Here we demonstrate the depletion of L2pB1 cells utilizing a transgenic mouse model expressing Diphtheria Toxin Receptors on their surface. After a course of 4 injections of 25ng of Diphtheria Toxin per gram bodyweight, we observed a successful depletion of L2pB1 cell population. Further studies are underway investigating the effects of a high fat diet on these L2pB1 depleted mice.en_US
dc.language.isoen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectImmunologyen_US
dc.subjectB1a cellsen_US
dc.subjectB cellsen_US
dc.subjectDepletionen_US
dc.subjectDiabetesen_US
dc.subjectDiphtheria toxinen_US
dc.subjectTransgenic miceen_US
dc.titleL2PB1 cell depletion with diphtheria toxin in PD-L2 KIKO miceen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2016-04-08T20:13:24Z
dc.description.embargo2017-04-01T00:00:00Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International