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dc.contributor.authorPark, Tae Wooen_US
dc.date.accessioned2016-04-26T18:48:16Z
dc.date.available2016-04-26T18:48:16Z
dc.date.issued2015
dc.identifier.urihttps://hdl.handle.net/2144/16100
dc.description.abstractOBJECTIVE: To study the association between benzodiazepine prescribing patterns including dose, type and dosing schedule and the risk of drug overdose death among US veterans receiving opioid analgesics. DESIGN: Case-cohort study SETTING: Veterans Health Administration (VHA), 2004 through 2009. PARTICIPANTS: US veterans, primarily male, who received opioid analgesics between 2004 and 2009. All veterans who died of a drug overdose (n = 2,400) while receiving opioid analgesics and a random sample of veterans (n = 420,386) who received VHA medical services and opioid analgesics were included in the study. Main outcome measure: Drug overdose death, defined as any intentional, unintentional or indeterminate poisoning death caused by any medication or drug, determined by cause of death information from the National Death Index. RESULTS: Twenty seven percent of veterans who received opioid analgesics also received benzodiazepines during the study period. Approximately half of the drug overdose deaths (n=1,185) occurred when veterans were concurrently prescribed benzodiazepines and opioids. Risk of drug overdose death increased based on benzodiazepine prescription history: formerly prescribed vs. not prescribed (adjusted hazard ratio [HR]=2.33, 95% confidence interval [CI]: 2.05-2.64); currently prescribed vs. not prescribed (HR=3.86, CI:3.49-4.26). Risk of drug overdose death increased as daily benzodiazepine dose increased. When compared to clonazepam, temazepam was associated with a decreased drug overdose death risk (HR=0.63, CI: 0.48-0.82). Benzodiazepine dosing schedule was not associated with drug overdose death risk. CONCLUSIONS: Among veterans receiving opioid analgesics, receipt of benzodiazepines was associated with an increased risk of drug overdose death in a dose-response fashion.en_US
dc.language.isoen_US
dc.subjectMedicineen_US
dc.subjectBenzodiazepinesen_US
dc.subjectDrug overdose deathen_US
dc.subjectOpioid analgesicsen_US
dc.titleBenzodiazepine prescribing patterns and drug overdose deaths among individuals receiving opioid analgesicsen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2016-04-08T20:42:43Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineEpidemiologyen_US
etd.degree.grantorBoston Universityen_US


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