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dc.contributor.authorMustaly, Hatim Mustafa
dc.date.accessioned2016-05-02T15:32:46Z
dc.date.available2016-05-02T15:32:46Z
dc.date.issued2015
dc.identifier.urihttps://hdl.handle.net/2144/16121
dc.description.abstractThe Hippo signaling pathway, originally identified in Drosophila melanogaster and later shown to be conserved in mammals, is essential in regulating organ size and maintaining tissue homeostasis. It is now clear that functional inactivation of the Hippo pathway is common in variety of cancers and promotes their development and progression. This suggests re-activation of Hippo pathway activity may prove an effective anti-cancer therapy. Here, we describe two small molecule activators of the Hippo pathway that we have recently uncovered from a focused small-molecule inhibitor screen.en_US
dc.language.isoen_USen_US
dc.subjectPharmacologyen_US
dc.titleIdentification of small molecule modulators of the Hippo tumor suppressor pathwayen_US
dc.typeThesis/Dissertation
dc.date.updated2016-04-08T20:16:08Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


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