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dc.contributor.authorSharifzadeh, Aryaen_US
dc.date.accessioned2016-05-02T18:09:06Z
dc.date.available2016-05-02T18:09:06Z
dc.date.issued2015
dc.identifier.urihttps://hdl.handle.net/2144/16129
dc.description.abstractIdiopathic macular hole is a disease of the eye with unknown cause, but a pathology that, over the course of several decades of investigation by clinicians and researchers alike, has become readily treatable with surgical intervention at a very high rate of successful repair. The current study presents a retrospective case series exploring surgical outcomes for treatment of recurrent macular holes. The study additionally provides a window into the past, present, and future of macular holes across all clinical considerations, and importantly performs a supplementary statistical meta analysis of reoperation success rates in the relevant field of published data- the first of its kind. The introductory background of the present study establishes a natural history of idiopathic macular holes in clinical discovery, classification, and management. The study's case series data specifically focuses on the phenomenon of macular hole recurrence, offering surgical outcome measures of patients undergoing primary and secondary repair operations in a single-center, single-surgeon design. The findings of the retrospective series support the hypothesis that macular hole reoperation does achieve successful anatomical closure in a majority of cases. A meta analysis performed on the current field of published clinical research pertaining to recurrent macular holes established cumulative success rates across a variety of surgical conditions. The present study's findings were then compared to the corresponding measures across the landscape of recurrent macular hole literature, to help inform a niche of clinical research that continues to be an area of investigation and discovery. In presenting a cohesive, synthesized narrative of recurrent macular holes, the study provides a foundation wherein ongoing collaborative efforts in the field can continue to build upon a blueprint currently set in place, and work towards finding a cause behind an otherwise idiopathic disease.en_US
dc.language.isoen_US
dc.subjectSurgeryen_US
dc.subjectHoleen_US
dc.subjectMacularen_US
dc.subjectRetinaen_US
dc.subjectVitrectomyen_US
dc.titleSurgical outcomes of recurrent macular holeen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2016-04-08T20:16:29Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


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