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dc.contributor.authorHafften, Nicholasen_US
dc.date.accessioned2016-05-02T19:03:45Z
dc.date.available2016-05-02T19:03:45Z
dc.date.issued2015
dc.identifier.urihttps://hdl.handle.net/2144/16134
dc.description.abstractResearch into the gut microbiome has revealed the widespread influence that microbial species have on their host. Host genetics and environmental factors influence the abundance and diversity of the bacterial species living within the gastrointestinal tract. When the normal composition of the gut microbiota is altered, a dysbiotic state incurs. Inflammatory bowel disease (IBD) is a chronic/relapsing inflammatory disorder of the intestinal mucosa, which is characterized by a state of dysbiosis. Despite the large amount of information studying the role dysbiosis has in the pathogenesis of IBD, it is not clear how the altered microbial composition of the gut in IBD patients leads to susceptibility to enteric pathogens such as Clostridium difficile. This study aims to highlight the features of the gastrointestinal tract that are modified as a result of dysbiosis in the IBD population, and how these features facilitate colonization by C. difficile and symptom development. Review of the available literature demonstrated that the depletion of Clostridial cluster XIVa in IBD-associated dysbiosis alters bile acid metabolism and butyrate fermentation in the colon, ultimately promoting germination of C. difficile spores and weakening the gut's immune response against toxin-mediated inflammation. From continued research into the gut microbiota, more will be understood of how these microbial organisms influence human health and disease.en_US
dc.language.isoen_US
dc.subjectMedicineen_US
dc.subjectClostridium difficileen_US
dc.subjectGut microbiotaen_US
dc.subjectInflammatory bowel diseaseen_US
dc.subjectBile aciden_US
dc.subjectButyrateen_US
dc.titleDysbiosis in inflammatory bowel disease promotes clostridium difficile colonizationen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2016-04-08T20:16:37Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


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