Show simple item record

dc.contributor.authorHsu, Alexanderen_US
dc.date.accessioned2016-07-12T15:29:52Z
dc.date.available2016-07-12T15:29:52Z
dc.date.issued2016
dc.identifier.urihttps://hdl.handle.net/2144/17013
dc.description.abstractDiversity in excitatory synaptic transmission by cortical pyramidal neurons give rise to the possibility of different neuronal networks that mediate distinct cortical function. Understanding heterogeneity of excitatory input to pyramidal neurons across distinct cortical areas and species will provide insight into cortical specialization and, ultimately, selective vulnerability of cortical areas to neuropathology in humans. In a previous study in our laboratory (Medalla and Luebke, 2015), significant differences in the ultrastructural features of excitatory asymmetric synapses in layers 2-3 (L2-3) neuropil were found between two distinct cortical areas in the rhesus monkey – primary sensory visual (V1) versus higher-order lateral prefrontal (LPFC) cortices. Here, we used serial sectioning electron microscopy to determine whether these differences in synaptic elements also exist in the corresponding visual (V1) and frontal (FC) cortices in the mouse. Multiple analyses of L2-3 neuropil of FC and V1 in mouse revealed three fundamental principles. First, in contrast to the diverse synapses in monkey LPFC and V1, asymmetric axospinous synapses in L2-3 neuropil of mouse FC and V1 are remarkably homogenous with regard to presynaptic and postsynaptic entities. Second, asymmetric axospinous synapses in L2-3 neuropil of mouse V1 resemble that of monkey V1 in postsynaptic entities, but differ in presynaptic entity. Third, asymmetric axospinous synapses in L2-3 neuropil of mouse FC and monkey LPFC differ substantially in both presynaptic and postsynaptic entities. These findings have broad implications for extrapolation of excitatory synaptic transmission data from one cortical area to another, and also from one species to another.en_US
dc.language.isoen_US
dc.subjectNeurosciencesen_US
dc.subjectExcitatoryen_US
dc.subjectMonkeyen_US
dc.subjectMouseen_US
dc.subjectSynapsesen_US
dc.subjectCortical diversityen_US
dc.subjectSerial electron microscopyen_US
dc.titleComparison of excitatory synapses in diverse cortical areas of the mouse and monkeyen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2016-06-18T22:28:52Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineAnatomy & Neurobiologyen_US
etd.degree.grantorBoston Universityen_US


This item appears in the following Collection(s)

Show simple item record