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dc.contributor.authorKennedy, James Morganen_US
dc.date.accessioned2016-07-12T18:53:24Z
dc.date.available2016-07-12T18:53:24Z
dc.date.issued2016
dc.identifier.urihttps://hdl.handle.net/2144/17016
dc.description.abstractSleep loss alters both the concentration and activity of various aspects of the immune system. These alterations lead to increased susceptibility to infection and the progression of pathologies such as insulin resistance and atherosclerosis. Two proposed mechanisms of this alteration in immune function are the changes in both cortisol and sympathetic nervous system activity that accompany sleep deprivation. This work reviewed literature that measured the effects of periods of sleep restriction upon both cortisol and catecholamine concentrations within human subjects. Furthermore, studies which measured the effects of sleep loss upon these hormone levels and the associated changes in immune parameters were included. This thesis asserts that there is no defined pattern in reference to alterations of cortisol levels as a result of sleep deprivation. Furthermore, more evidence must be collected before implementing cortisol as a main effector of sleep loss upon immune system function. This dissertation, although repeatedly noting increased levels of norepinephrine following periods of sleep restriction, similarly argues that more research must be completed in order to declare that altered catecholamine concentrations as a result of sleep loss is a mechanism for altered immune function.en_US
dc.language.isoen_US
dc.subjectImmunologyen_US
dc.subjectCatecholaminesen_US
dc.subjectCortisolen_US
dc.subjectEpinephrineen_US
dc.subjectImmune systemen_US
dc.subjectNorepinephrineen_US
dc.subjectSleep deprivationen_US
dc.titleEffects of sleep deprivation on immune function via cortisol and catecholaminesen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2016-06-18T22:28:54Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


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