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dc.contributor.authorFlynn, Erin Elizabethen_US
dc.date.accessioned2016-11-16T18:36:05Z
dc.date.available2016-11-16T18:36:05Z
dc.date.issued2016
dc.identifier.urihttps://hdl.handle.net/2144/19174
dc.description.abstractThis paper outlines the progression of age-related macular degeneration in the eye and discusses the diagnostic approaches and therapies used currently to treat this disease. Age-related macular degeneration has a complicated pathophysiology involving genetic and environmental factors. This paper focuses its attention on the role of lipofuscin accumulation in this disease. Lipofuscin in the eye refers to the bisretinoid products of the visual cycle. While lipofuscin accumulation is normal in healthy eyes, the excessive accumulation causes retinal dysfunction. Lipofuscin accumulation has been linked heavily not only to age-related macular degeneration but also juvenile macular degeneration, retinitis pigmentosa, Best’s Villiform disease, and many others. New techniques in ophthalmic research have evaluated the role of lipofuscin accumulation in such retinal genetic diseases. This paper proposes an approach to apply techniques such as quantified autofluorescence imaging and high-powered liquid chromatography of bisretinoids in the eye to track the role of lipofuscin accumulation in the progression of age-related macular degeneration.en_US
dc.language.isoen_US
dc.rightsAttribution-NoDerivatives 4.0 Internationalen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/
dc.subjectMedicineen_US
dc.subjectAMDen_US
dc.subjectLipofuscinen_US
dc.subjectQAFen_US
dc.titleNon-invasive monitoring of lipofuscin: an imaging technique predictive for age-related macular degenerationen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2016-11-03T19:13:22Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


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Attribution-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NoDerivatives 4.0 International