Systemic vitamin D and fish oil in the management of psoriasis
Data from studies looking at the use of systemic vitamin D and omega-3 fatty acids independently in the treatment of psoriasis has shown that both these supplements have at least a modest effect when taken in above average doses. Recent advances in the understanding of the pathophysiology of psoriasis as well as the immunomodulatory and anti-inflammatory properties of these supplements suggest that they could have an additive effect in treating this life-long disease. The proposed study is a randomized placebo-controlled trial that aims to explore this supposition by supplying demographically diverse subjects, who have varying levels of psoriasis severity, with 4g of Omacor® fish oil (1.8g EPA + 1.5g DHA) and 4000IU of vitamin D3 (cholecalciferol) or placebo pills on top of their existing treatment regimen. The subjects will have a baseline evaluation and the trial will run for 1 year with 12 week follow up intervals. Every 12 weeks the subjects will have a clinician calculate their current PASI score and have blood drawn to measure vitamin D levels. Investigators will analyze the overall percent reduction of an individual’s PASI score as well as the mean final PASI scores of the intervention and control groups. The data from this study will provide information that could add another safe, inexpensive, and effective treatment modality to the dermatologist’s arsenal.