Boston University Libraries OpenBU
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    •   OpenBU
    • BU Open Access Articles
    • BU Open Access Articles
    • View Item
    •   OpenBU
    • BU Open Access Articles
    • BU Open Access Articles
    • View Item

    Fungal microbiota profile in newly-diagnosed treatment-naïve children with Crohn's disease

    Thumbnail
    Date Issued
    2016-11-03
    Publisher Version
    10.1093/ecco-jcc/jjw197
    Author(s)
    Korolev, Kirill
    El Mouzan, Mohammad
    Wang, Feng
    Al Mofarreh, Mohammad
    Menon, Rajita
    Al Barrag, Ahmad
    Al Sarkhy, Ahmad
    Al Asmi, Mona
    Hamed, Yassin
    Saeed, Anjum
    Dowd, Scot
    Assiri, Asaad
    Winter, Harland
    Share to FacebookShare to TwitterShare by Email
    Export Citation
    Download to BibTex
    Download to EndNote/RefMan (RIS)
    Metadata
    Show full item record
    Embargoed until:
    Indefinite
    Permanent Link
    https://hdl.handle.net/2144/19202
    Citation (published version)
    Mohammad El Mouzan, Feng Wang, Mohammad Al Mofarreh, Rajita Menon, Ahmad Al Barrag, Kirill S. Korolev, Ahmad Al Sarkhy, Mona Al Asmi, Yassin Hamed, Anjum Saeed, Scot Dowd, Asaad Assiri, Harland Winter. "Fungal Microbiota Profile in Newly-diagnosed Treatment-naïve Children with Crohn disease" Journal of Crohn's and Colitis, 2016 Nov 3, pii: jjw197.
    Abstract
    BACKGROUND & AIMS: although increasing evidence suggests a role for fungi in inflammatory bowel disease (IBD), data are scarce and mostly from adults. Our aim was to define the characteristics of fungal microbiota in newly-diagnosed treatment-naïve children with Crohn disease (CD). METHODS: The children referred for colonoscopy were prospectively enrolled in the study at King Khalid University Hospital, King Saud University and Al Mofarreh Polyclinics in Riyadh. Tissue and stool samples were collected and frozen till sequencing analysis. The children with confirmed CD diagnosis were designated as cases and the others as non- IBD controls. 78 samples were collected from 35 children (15 CD and 20 controls). Statistical analysis was performed to investigate CD associations and diversity. RESULTS: CD-associated fungi varied with the level of phylogenetic tree. There was no significant difference in abundance between normal and inflamed mucosa. Significantly abundant CD-associated taxa included Psathyrellaceae (p=0.01), Cortinariaceae (p= 0.04), Psathyrella (p= 0.004), and Gymnopilus (p=0.03).Monilinia was significantly depleted (p=0.03), whereas other depleted taxa, although not statistically significant, included Leotiomycetes (p= 0.06), Helotiales (p=0.08), Sclerotiniaceae (p=0.07). There was no significant difference in fungal diversity between CD and controls. CONCLUSIONS: We report highly significant fungal dysbiosis in newly diagnosed treatment naïve CD children. Depleted and more abundant taxa suggest anti-inflammatory and proinflamatory potentials respectively. Further studies with larger sample size including functional analysis are needed to clarify the significance of the fungal community in the pathogenesis of CD.
    Collections
    • BU Open Access Articles [3866]
    • ENG: Bioinformatics: Scholarly Papers [101]


    Boston University
    Contact Us | Send Feedback | Help
     

     

    Browse

    All of OpenBUCommunities & CollectionsIssue DateAuthorsTitlesSubjectsThis CollectionIssue DateAuthorsTitlesSubjects

    Deposit Materials

    LoginNon-BU Registration

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Boston University
    Contact Us | Send Feedback | Help