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    Human seizures couple across spatial scales through travelling wave dynamics

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    Attribution 3.0
    Date Issued
    2017-04-04
    Publisher Version
    10.1038/ncomms14896
    Author(s)
    Martinet, Louis-Emmanuel
    Fiddyment, Grant
    Madsen, J.R.
    Eskandar, E.N.
    Truccolo, Wilson
    Eden, Uri T.
    Cash, S.S.
    Kramer, Mark A.
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    Permanent Link
    https://hdl.handle.net/2144/21311
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    Published version
    Citation (published version)
    Martinet, L. E. et al. Human seizures couple across spatial scales through travelling wave dynamics. Nat. Commun. 8, 14896 doi: 10.1038/ncomms14896 (2017).
    Abstract
    Epilepsy-the propensity toward recurrent, unprovoked seizures-is a devastating disease affecting 65 million people worldwide. Understanding and treating this disease remains a challenge, as seizures manifest through mechanisms and features that span spatial and temporal scales. Here we address this challenge through the analysis and modelling of human brain voltage activity recorded simultaneously across microscopic and macroscopic spatial scales. We show that during seizure large-scale neural populations spanning centimetres of cortex coordinate with small neural groups spanning cortical columns, and provide evidence that rapidly propagating waves of activity underlie this increased inter-scale coupling. We develop a corresponding computational model to propose specific mechanisms-namely, the effects of an increased extracellular potassium concentration diffusing in space-that support the observed spatiotemporal dynamics. Understanding the multi-scale, spatiotemporal dynamics of human seizures-and connecting these dynamics to specific biological mechanisms-promises new insights to treat this devastating disease.
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    • BU Open Access Articles [3664]


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