Distinct progenitor lineages contribute to neuronal diversity in layer 4 of the barrel cortex
Guillamon Vivancos, Teresa
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A central question in the study of cortical development is how neural progenitors generate the many types of neurons that organize into distinct functional areas and layers. Using in vivo genetic fate-mapping, we previously showed that separate progenitor lineages specify distinct properties of layer 2/3 pyramidal neurons in the frontal cortex of the mouse. Here we interrogate whether this constitutes a general rule of cortical development by examining a different layer and area of the brain using the same approach. We show that neuronal diversity is also specified by progenitor type of origin in the earlier developing layer 4 of the barrel cortex, but that the differences in progeny are distinct from those specified for layer 2/3 in the frontal cortex. This elucidates a dynamic temporal program in progenitor classes, which fine-tunes the properties of their progeny according to the lamina of destination. Our results also demonstrate that distinct lineages contribute unique features of the barrel cortex topography, specifying daughter cell allocation, electrophysiological properties and synaptic contacts with the thalamus.
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