Show simple item record

dc.contributor.authorSchlain, Gabrielle Staren_US
dc.date.accessioned2017-09-07T18:16:14Z
dc.date.issued2017
dc.identifier.urihttps://hdl.handle.net/2144/23737
dc.description.abstractObesity and eating disorders represent a severe problem in Western societies. Both the increased availability of highly palatable foods and dieting are major risk factors contributing to the epidemic disorders of feeding. The purpose of this study was to characterize an animal model of maladaptive feeding induced by intermittent access to a palatable diet alternation in mice. In this study, mice were either continuously provided with standard chow food (Chow/Chow), or provided with standard chow for 2 days, with 1 day of access to a high-sucrose, palatable food (Chow/Palatable). Following stability of intake within the cycling paradigm, we investigated the effects of several pharmacological treatments: Naltrexone, an opioid antagonist, SR141716A (rimonabant), a type 1 cannabinoid receptor antagonist, and BD-1063, a type 1 sigma receptor antagonist. Over successive cycles, Chow/Palatable mice showed an escalation of palatable food intake within the first-hour of renewed access to palatable diet, and displayed hypophagia upon its removal. Naltrexone, SR141716A, and BD-1063 reduced overconsumption of palatable food during this first hour. Here we provide evidence of strong face and convergence validities in a palatable diet alternation model in the mouse, confirming multiple shared underlying mechanisms of pathological eating across species, and thus making it a useful therapeutic development tool.en_US
dc.language.isoen_US
dc.subjectPharmacologyen_US
dc.titleBehavioral and pharmacological characterization of a mouse model of palatable diet alternationen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2017-07-12T01:11:35Z
dc.description.embargo2019-07-11T00:00:00Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


This item appears in the following Collection(s)

Show simple item record