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dc.contributor.authorCaccaviello, John Charles
dc.date.accessioned2017-09-11T15:30:54Z
dc.date.available2017-09-11T15:30:54Z
dc.date.issued2017
dc.identifier.urihttps://hdl.handle.net/2144/23759
dc.description.abstractThe pharmacodynamic effects of Risperidone on the vestibular system were assessed via dynamic computed posturography in 12 healthy subjects (6 male). Subjects were administered 2 mg, orally, of Risperidone and assessed on the NeuroCom® Balance Master© system under varying conditions. The vestibular response was deductively quantified by first assessing balance with a static force plate and eyes closed (Condition 2), and then assessed on a dynamic force plate with eyes closed (Condition 5). On average, Condition 2 scores were 24.46 points higher than Condition 5 scores (95% CI [20.973, 27.957]). A Pearson correlation between scores in Condition 2 and 5 showed a significant, moderate positive correlation (r = .487, p <.001). A trend analysis showed the effect of time, post-dose, on equilibrium score to be linear in nature (p < .001). In conclusion, some, but not all, of the subjects involved in the study experienced diminished vestibular control after administration of Risperidone; this may be due to phenotypic differences or learning effects.en_US
dc.language.isoen_USen_US
dc.subjectNeurosciencesen_US
dc.subjectRisperidoneen_US
dc.subjectBalanceen_US
dc.subjectEquilibriumen_US
dc.subjectPharmacodynamicsen_US
dc.subjectPosturographyen_US
dc.subjectVestibular systemen_US
dc.titleThe effects of Risperidone on the vestibular system of healthy volunteers as assessed by dynamic computed posturographyen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2017-07-12T19:18:03Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineAnatomy & Neurobiologyen_US
etd.degree.grantorBoston Universityen_US


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